cMOF Evidence Base
Other — Highly Effective Generation of Singlet Oxygen by an Imidazole-Linked Robust Photosensitizing Covalent Organic Framework

Measurement evidence

Other

Highly Effective Generation of Singlet Oxygen by an Imidazole-Linked Robust Photosensitizing Covalent Organic Framework · Luan T.-X., Du L., Wang J.-R. et al. · ACS Nano · 2022 · 21565-21575

2 measurement groups · 8 results

Reported values remain attached to the sample, method, conditions, extraction quality and source location that produced them.

MTT cytotoxicity assay, CLSM singlet oxygen assay, and in vitro photodynamic therapy

PC@PyPor-COF composite · Powder

4T1 and L929 cells; PC@PyPor-COF concentrations 0-400 ug/mL for cytotoxicity; 660 nm laser, 20 mW cm-2, 5-10 min irradiation for PDT/CLSM.

Temperature
310
Atmosphere
cell culture
Context
application composite
Measurement source
21572 · Results and Discussion · Figure 5c-e; Figures S17-S18
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
low cytotoxicity concentration thresholdnearly no obvious effect on 4T1 viability and only slight L929 inhibition even at 200 ug/mL——Text
Rounded Reported		21572 · Results and Discussion · Figure 5c
IC50 under laser irradiationMarked as a best value within this paper62.54 ug/mL——Text
Exact Reported		21572 · Results and Discussion · Figure S18
IC90 under laser irradiationMarked as a best value within this paper202.37 ug/mL——Text
Exact Reported		21572 · Results and Discussion · Figure S18
PDT laser condition660 nm, 20 mW cm-2, 10 min for anticancer efficacy/IC values——Text
Exact Reported		21572 · Results and Discussion · Figure S18
4T1 cancer-cell survival after PC@PyPor-COF plus laserMarked as a best value within this paperless than 20% survived——Text
Approximate		21572 · Results and Discussion · Figure 5e; Figure S17

thermogravimetric analysis and chemical stability PXRD

X-ray diffraction and scatteringThermogravimetric analysis

activated PyPor-COF · Powder

TGA under N2 from room temperature to 800 deg C at 10 deg C min-1; PXRD after immersion in acid/base/organic/aqueous solutions.

Atmosphere
N2 for TGA
Context
pristine COF
Measurement source
21570 · Results and Discussion · Figure 2d,e
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
PXRD stability after solution immersionmain peaks well-maintained after immersion in organic and aqueous solutions with strong acid and base——Text
Qualitative		21570 · Results and Discussion · Figure 2e
thermal stability thresholdMarked as a best value within this paperstable up to 300 deg C573.15 K—Text
Rounded Reported		21570 · Results and Discussion · Figure 2d
weight loss by 800 deg Cgradual weight loss of 20% to 800 deg C——Text
Rounded Reported		21570 · Results and Discussion · Figure 2d