Sensing Application — A Sensing Platform Based on Ni/Mn Bimetal-Organic Framework for Electrochemical Detection of Osimertinib

7 measurement groups · 34 results

Reported values remain attached to the sample, method, conditions, extraction quality and source location that produced them.

Amperometry calibration

Ni/Mn-MOF/GCE · Electrode

0.1 M NaOH with successive OSIM additions; constant potential +0.36 V; calibration over 0.5-800 uM and 800-1800 uM; n = 4.

Atmosphere: not reported
Geometry: Ni/Mn-MOF/GCE working electrode
Context: MOF-modified composite electrode
Measurement source: p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6A-B

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
First amperometric linear range upper bound	800 uM	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
First amperometric linear range lower bound	0.5 uM	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
Second amperometric linear range upper bound	1800 uM	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
Second amperometric linear range lower bound	800 uM	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
Amperometric operating potential	+0.36 V	—	—	Caption Exact Reported	p008 · Figure caption · Fig. 6
Calibration intercept for 0.5-800 uM OSIM	10.541 uA	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
Calibration intercept for 800-1800 uM OSIM	99.15 uA	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
Calibration R2 for 0.5-800 uM OSIM	R2 = 0.9985	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
Calibration R2 for 800-1800 uM OSIM	R2 = 0.9916	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
Calibration slope for 0.5-800 uM OSIMMarked as a best value within this paper	I (uA) = 0.1663 [OSIM] (uM) + 10.541	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
Calibration slope for 800-1800 uM OSIM	I (uA) = 0.055 [OSIM] (uM) + 99.15	—	—	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B
OSIM limit of detectionMarked as a best value within this paper	LOD = 0.16 uM (S/N = 3)	—	S/N = 3	Text Exact Reported	p008 · Amperometric Sensing of OSIM on MOF/GCE · Fig. 6B

Cyclic voltammetry concentration series

Voltammetry

Ni/Mn-MOF/GCE · Electrode

CV responses of Ni/Mn-MOF/GCE with OSIM additions from 0 to 0.05 mM in 0.1 M NaOH.

Atmosphere: not reported
Geometry: Ni/Mn-MOF/GCE working electrode
Context: MOF-modified composite electrode
Measurement source: p006-p007 · Cyclic Voltammetric Responses of OSIM · Fig. 5D

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
CV OSIM concentration-series maximum	0 to 0.05 mM OSIM	50 uM	—	Caption Exact Reported	p006-p007 · Cyclic Voltammetric Responses of OSIM · Fig. 5D

Amperometric repeatability

Ni/Mn-MOF/GCE · Electrode

Five consecutive amperometric measurements of 40 uM OSIM using one Ni/Mn-MOF/GCE at +0.36 V; n = 3.

Atmosphere: not reported
Geometry: single modified GCE
Context: MOF-modified composite electrode
Measurement source: p008-p009 · Reproducibility, Repeatability, and Stability of the MOF/GCE · Fig. 8B

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Number of repeatability measurements	five repetitive OSIM amperometric signals	—	—	Caption Exact Reported	p009 · Figure caption · Fig. 8B
Repeatability RSD on one electrode	RSD = 2.9%	—	—	Text Exact Reported	p008 · Reproducibility, Repeatability, and Stability of the MOF/GCE · Fig. 8B

Amperometric reproducibility

Ni/Mn-MOF/GCE · Electrode

Five separately prepared Ni/Mn-MOF/GCE electrodes tested toward 60 uM OSIM in NaOH at +0.36 V; n = 3.

Atmosphere: not reported
Geometry: five modified GCEs
Context: MOF-modified composite electrode
Measurement source: p008-p009 · Reproducibility, Repeatability, and Stability of the MOF/GCE · Fig. 8A

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Number of electrodes in reproducibility test	five Ni/Mn-MOF/GCE electrodes	—	—	Caption Exact Reported	p009 · Figure caption · Fig. 8A
Reproducibility RSD across five electrodes	RSD = 2.7%	—	—	Text Exact Reported	p008-p009 · Reproducibility, Repeatability, and Stability of the MOF/GCE · Fig. 8A

Amperometric interference/selectivity test

Chronoamperometry

Ni/Mn-MOF/GCE · Electrode

0.1 mM OSIM and tenfold concentrations of gefitinib, ibrutinib, vandetanib, apixaban, riboflavin and tryptophan in 0.1 M NaOH at +0.36 V; n = 3.

Atmosphere: not reported
Geometry: Ni/Mn-MOF/GCE working electrode
Context: MOF-modified composite electrode
Measurement source: p008 · Selectivity of the MOF/GCE · Fig. 7

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Interferent response	interference analyte additions gave insignificant responses compared with OSIM oxidation	—	—	Text Qualitative	p008 · Selectivity of the MOF/GCE · Fig. 7
Interferent concentration ratio	tenfold concentration of GF, IB, VA, AP, RF and Trp	—	—	Text Exact Reported	p008 · Selectivity of the MOF/GCE · Fig. 7
Selectivity-test OSIM concentration	0.1 mM OSIM	100 uM OSIM	—	Caption Exact Reported	p008 · Figure caption · Fig. 7

Standard addition amperometry in blood serum

Ni/Mn-MOF/GCE · Electrode

Blood serum ultrafiltered at 5000 rpm for 20 min; OSIM standards spiked every 50 s in 0.1 M NaOH; amperometry at +0.36 V; n = 3.

Atmosphere: not reported
Geometry: Ni/Mn-MOF/GCE working electrode
Context: MOF-modified composite electrode in real-sample matrix
Measurement source: p009 · MOF/GCE Performance in the Actual Sample · Fig. 9; Table 1

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Serum recovery range maximum	101.71%	—	—	Text Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum recovery range minimum	98%	—	—	Text Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum RSD upper bound	RSD lower than 1.31%	—	upper bound	Text Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 1 OSIM found	Added 0.00 uM; found not detected	—	—	Table Qualitative	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 2 OSIM found	Added 0.50 uM; found 0.49 uM; recovery 98.00%; RSD 1.03%	—	RSD 1.03%	Table Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 2 recovery	98.00%	—	RSD 1.03%	Table Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 3 OSIM found	Added 2.00 uM; found 2.51 uM; recovery 100.40%; RSD 0.87%	—	RSD 0.87%	Table Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 3 recovery	100.40%	—	RSD 0.87%	Table Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 4 OSIM found	Added 5.00 uM; found 7.49 uM; recovery 99.86%; RSD 1.31%	—	RSD 1.31%	Table Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 4 recovery	99.86%	—	RSD 1.31%	Table Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 5 OSIM found	Added 10.00 uM; found 17.8 uM; recovery 101.71%; RSD 0.94%	—	RSD 0.94%	Table Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1
Serum sample 5 recovery	101.71%	—	RSD 0.94%	Table Exact Reported	p009 · MOF/GCE Performance in the Actual Sample · Table 1

Amperometric long-term stability

Ni/Mn-MOF/GCE · Electrode

30 uM OSIM in NaOH at +0.36 V; current monitored for 35 min; n = 3.

Atmosphere: not reported
Geometry: Ni/Mn-MOF/GCE working electrode
Context: MOF-modified composite electrode
Measurement source: p008-p009 · Reproducibility, Repeatability, and Stability of the MOF/GCE · Fig. 8C

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Current retained after long-term stability test	almost 96% after 35 min	—	almost	Text Approximate	p008 · Reproducibility, Repeatability, and Stability of the MOF/GCE · Fig. 8C
Long-term stability duration	35 min	—	—	Text Exact Reported	p008 · Reproducibility, Repeatability, and Stability of the MOF/GCE · Fig. 8C