Electrochemistry Application — ZnS/MnO2 metal organic framework based conductive hydrogel for highly selective and sensitive detection of glutathione in serum samples

3 measurement groups · 22 results

Reported values remain attached to the sample, method, conditions, extraction quality and source location that produced them.

Cyclic voltammetry (CV)

Voltammetry

2 wt% ZnS/MnO2-MOF hydrogel electrode · Electrode

Three-electrode cell on CHI 660E workstation; hydrogel working electrode, platinum counter, Ag/AgCl reference in 0.1 M KCl; 0.1 M KCl with 5 mM Fe(CN)6^3-/4- at pH 7.4; potential range -0.1 to 0.5 V vs Ag/AgCl; with and without 10 nM GSH.

Geometry: 1 cm x 1 cm hydrogel substrate as working electrode.
Context: Composite hydrogel electrode; comparison is analyte absent versus 10 nM GSH present, not a pristine-MOF control.
Measurement source: p.4 · 2.6. Electrochemical analysis · Fig. 5(a)

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Oxidation current density without GSH	0.78 mAcm^-2	—	—	Text Exact Reported	p.6 · 3.3. Electrochemical analysis and optimization · Fig. 5(a)
Reduction current density without GSH	-0.72 mAcm^-2	—	—	Text Exact Reported	p.6 · 3.3. Electrochemical analysis and optimization · Fig. 5(a)
Oxidation current density with 10 nM GSHMarked as a best value within this paper	2.25 mAcm^-2	—	—	Text Exact Reported	p.6 · 3.3. Electrochemical analysis and optimization · Fig. 5(a)
Oxidation peak potential with 10 nM GSH	0.27 V	—	—	Text Exact Reported	p.6 · 3.3. Electrochemical analysis and optimization · Fig. 5(a)
Reduction current density with 10 nM GSH	-1.67 mAcm^-2	—	—	Text Exact Reported	p.6 · 3.3. Electrochemical analysis and optimization · Fig. 5(a)
Reduction peak potential with 10 nM GSH	0.12 V	—	—	Text Exact Reported	p.6 · 3.3. Electrochemical analysis and optimization · Fig. 5(a)
Optimised ZnS/MnO2-MOF loading in hydrogelMarked as a best value within this paper	2 wt%	—	—	Text Exact Reported	p.6 · 3.3. Electrochemical analysis and optimization · Fig. S2(a)
Optimised supporting electrolyte pHMarked as a best value within this paper	pH 7.4	—	—	Text Exact Reported	p.7 · 3.3. Electrochemical analysis and optimization · Fig. S2(b)

CV scan-rate study

Voltammetry

2 wt% ZnS/MnO2-MOF hydrogel electrode · Electrode

0.1 M PBS electrolyte with 10 nM GSH; scan rates 10, 30, 50, 70, 90, 110 and 130 mV/s.

Geometry: Hydrogel working electrode.
Context: Composite hydrogel sensor kinetics.
Measurement source: p.7 · 3.3. Electrochemical analysis and optimization · Fig. 5(b,c)

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
CV scan-rate range lower bound	10 mV/s	—	—	Text Exact Reported	p.7 · 3.3. Electrochemical analysis and optimization · Fig. 5(b)
Optimal CV scanning rateMarked as a best value within this paper	50 mV/s	—	—	Text Exact Reported	p.7 · 3.3. Electrochemical analysis and optimization · Fig. 5(b)
Peak current versus square-root scan-rate regression R2	R2 of 0.995	—	—	Text Exact Reported	p.7 · 3.3. Electrochemical analysis and optimization · Fig. 5(c)
Peak current versus scan-rate calibration slope	slope value measuring 3.52	—	—	Text Exact Reported	p.7 · 3.3. Electrochemical analysis and optimization · Fig. 5(c)
CV scan-rate range upper bound	130 mV/s	—	—	Text Exact Reported	p.7 · 3.3. Electrochemical analysis and optimization · Fig. 5(b)

Performance optimisation from current bar plots

2 wt% ZnS/MnO2-MOF hydrogel electrode · Electrode

SI Fig. S2(a) compares 1-4 wt% ZnS/MnO2-MOF hydrogel; SI Fig. S2(b) compares pH 3, 5, 7, 9 and 11 electrolytic solutions.

Geometry: Hydrogel sensor electrode.
Context: Composite hydrogel optimisation for GSH response.
Measurement source: p.2 · Supplementary Information · Figure S2

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Estimated current at 1 wt% ZnS/MnO2-MOF loading	~0.0015 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(a)
Estimated current at 2 wt% ZnS/MnO2-MOF loadingMarked as a best value within this paper	~0.0025 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(a)
Estimated current at 3 wt% ZnS/MnO2-MOF loading	~0.0019 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(a)
Estimated current at 4 wt% ZnS/MnO2-MOF loading	~0.0020 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(a)
Estimated current at pH 11	~0.0027 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(b)
Estimated current at pH 3	~0.0025 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(b)
Estimated current at pH 5	~0.0024 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(b)
Estimated current at pH 7Marked as a best value within this paper	~0.0028 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(b)
Estimated current at pH 9	~0.0026 mA	—	—	Figure Axis Approximate	p.2 · Supplementary Information · Figure S2(b)