Synthesis evidence

Contorted hexabenzocoronene-based two-dimensional conductive metal-organic framework enabled electrochemical platform for monitoring of rutin in pharmaceuticals and biological samples

Wang S., Li P., Wang M. et al. · Electrochimica Acta · 2025 · 146933

2 structured synthesis routes

Completeness describes how fully the route could be reconstructed from the main article and supporting information.

Complete recipeSource: Main

Route 1: Solvothermal

2 · 2.3. Synthesis of Cu3(HBC)2

Metal precursorsCu(NO3)2.3H2O, 9.6 mg (0.04 mmol)
Linker precursorsHBC, 7.0 mg (0.01 mmol); HBC itself was synthesised according to literature [29,33]
Solvents2 mL water for Cu(NO3)2.3H2O; 0.5 mL N,N-dimethylacetamide (DMAc) for HBC
Atmospherenot specified
Temperature85
Time72
Work-upcool to room temperature; collect by centrifugation; wash successively with water, DMF, and THF
Activationdried under vacuum
Scalability contextNo scale-up experiment reported; small-batch synthesis used milligram precursor quantities.
Show 4 structured reagent records
RoleReagentAmount / concentrationSource
Metal SourceCu(NO3)2.3H2O9.6 mg (0.04 mmol)2 · 2.3. Synthesis of Cu3(HBC)2
LinkerHBC7.0 mg (0.01 mmol)2 · 2.3. Synthesis of Cu3(HBC)2
Solventwater2 mL2 · 2.3. Synthesis of Cu3(HBC)2
SolventN,N-dimethylacetamide (DMAc)0.5 mL2 · 2.3. Synthesis of Cu3(HBC)2
Complete recipeSource: Main

Route 2: Drop Cast

2 · 2.4. Modification of the SPEs

Solventsdeionised water
Atmosphereair
Temperature37
Substrate orientationscreen-printed carbon working electrode surface
Work-upultrasonicate Cu3(HBC)2 in 1 mL water for 30 min; drop coat 2 uL aliquot; dry in forced-air oven
Activationstored at room temperature before use
Scalability contextDrop-cast modification on disposable SPE; authors note simple fabrication, compact size, disposability, and ease of mass production.
Show 2 structured reagent records
RoleReagentAmount / concentrationSource
OtherCu3(HBC)2dispersion in 1 mL water; 2 uL aliquot drop-coated · optimised at 0.5 mg/mL2 · 2.4. Modification of the SPEs
Solventdeionized water1 mL2 · 2.4. Modification of the SPEs