Synthesis evidence

Highly sensitive electrochemiluminescence glucose sensor under alkaline conditions based on glucose oxidase@conductive metal-organic framework nanocapsules

Mao M., Li L., Huang C. et al. · Sensors and Actuators B: Chemical · 2025 · 137595

2 structured synthesis routes

Completeness describes how fully the route could be reconstructed from the main article and supporting information.

Complete recipeSource: SI

Route 1: Other

p004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP

Metal precursors2 mL Zn(CH3COO)2 solution (206 mM)
Linker precursors2 mL aqueous 2.72 M 2-methylimidazole (2-MeIm)
Solventswater
Additives2 mg PVP; 0.5 mg GOx; 0.5 mg L-cysteine (Cys)
Atmospherenot reported; room-temperature ambient handling implied
Temperatureroom temperature; vacuum dried at 37 degC
Time0.033 h initial stir + 0.050 h after Cys addition + 1.5 h ageing + 12 h vacuum drying
Work-upcentrifugation at 6000 rpm for 5 min; washed three times with water
Activationvacuum-dried at 37 degC for 12 h and stored in powder form
Scalability contextMilligram-scale batch; no scale-up discussion.
Show 6 structured reagent records
RoleReagentAmount / concentrationSource
Linker2-methylimidazole (2-MeIm)2 mL aqueous solution · 2.72 Mp004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP
Additivepolyvinylpyrrolidone (PVP)2 mgp004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP
Otherglucose oxidase (GOx)0.5 mgp004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP
AdditiveL-cysteine (Cys)0.5 mgp004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP
Metal SourceZn(CH3COO)22 mL solution · 206 mMp004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP
SolventwaterNot specifiedp004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP
Complete recipeSource: SI

Route 2: Other

p004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP

Metal precursors10 mg GOx@ZIF-8 precursor containing Zn
Linker precursors12 mg HHTP ligand
Solventsethanol/water solvent, volume ratio 7:1
AdditivesGOx retained from GOx@ZIF-8 precursor
Atmospherenot reported; room-temperature ambient standing implied
Temperatureroom temperature; vacuum dried at 37 degC
Time12 h standing + 12 h vacuum drying
Work-upcentrifugation at 10000 rpm for 3 min; washed three times with water and ethanol, respectively
Activationvacuum-dried at 37 degC for 12 h and stored in powder form
Scalability context10 mg precursor conversion; no scale-up discussion.
Show 3 structured reagent records
RoleReagentAmount / concentrationSource
OtherGOx@ZIF-8 precursor10 mgp004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP
LinkerHHTP12 mgp004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP
Solventethanol/watervolume ratio 7:1p004 · Experimental Procedure: Procedures for synthesis of GOx@Zn-HHTP