Sensing Application — Conductive Metal-Organic Frameworks for Amperometric Sensing of Paracetamol

7 measurement groups · 22 results

Reported values remain attached to the sample, method, conditions, extraction quality and source location that produced them.

Differential pulse voltammetry (DPV) calibration for paracetamol

Voltammetry

NiCu-CAT/GCE sensing electrode · Electrode

Paracetamol concentrations of 5, 10, 15, 20, 25, 30, 35, 40, 50, 70, 90, 110, 150 and 190 uM on NiCu-CAT/GCE under optimised conditions.

Temperature: 298.15
Geometry: Three-electrode cell; NiCu-CAT/GCE working electrode, Pt wire counter electrode, Ag/AgCl reference electrode.
Context: Composite NiCu-CAT/Nafion/GCE sensing electrode.
Measurement source: main pp.6-7 · Analytical Performance Characteristics · Figure 5

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
DPV calibration intercept	1.9019 uA	—	R2 = 0.9993	Text Exact Reported	main p.7 · Analytical Performance Characteristics · Figure 5B
DPV calibration slopeMarked as a best value within this paper	Ipa (uA) = 0.1473 c(uM) + 1.9019; R2 = 0.9993	—	R2 = 0.9993	Text Exact Reported	main p.7 · Analytical Performance Characteristics · Figure 5B
Paracetamol DPV linear detection rangeMarked as a best value within this paper	5-190 uM	—	range	Text Range	main p.7 · Analytical Performance Characteristics · Figure 5A-B
Paracetamol limit of determinationMarked as a best value within this paper	near 5 uM	—	near	Text Approximate	main p.7 · Analytical Performance Characteristics · Figure 5B

DPV selectivity / interference test

Voltammetry

NiCu-CAT/GCE sensing electrode · Electrode

40 uM paracetamol with 5-fold dopamine and ascorbic acid; 100-fold K+, Cd2+, Cu2+, Pb2+, Fe3+, Al3+, SO4^2- and Cl-.

Temperature: 298.15
Geometry: NiCu-CAT/GCE working electrode in three-electrode DPV setup.
Context: Composite NiCu-CAT/Nafion/GCE sensing electrode.
Measurement source: main p.7 · Discussion - Reproducibility, Stability and Interference · Figure 6c-d

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Inorganic ion interferent tolerance	40 uM PA not affected by 100-fold K+, Cd2+, Cu2+, Pb2+, Fe3+, Al3+, SO4^2- and Cl-	—	—	Text Qualitative	main p.7 · Discussion - Reproducibility, Stability and Interference · Figure 6d
Organic interferent tolerance	40 uM PA not affected by 5-fold dopamine and ascorbic acid	—	—	Text Qualitative	main p.7 · Discussion - Reproducibility, Stability and Interference · Figure 6c

DPV real-sample tablet analysis

Voltammetry

NiCu-CAT/GCE sensing electrode · Electrode

Commercial Tylenol tablet nominally containing 650 mg paracetamol; tablets ground, dissolved with ethanol, filtered and diluted with phosphate buffer solution.

Temperature: 298.15
Geometry: NiCu-CAT/GCE working electrode in three-electrode DPV setup.
Context: Composite NiCu-CAT/Nafion/GCE sensing electrode.
Measurement source: main p.7 · Real Sample Analysis · Supplementary Table 1

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Nominal commercial tablet paracetamol amount	650 mg	—	—	Text Exact Reported	main p.7 · Real Sample Analysis
Commercial tablet paracetamol recovery range	97.23-103.8%	—	range	SI Table Range	SI p.4 · Supplementary Table 1 · Supplementary Table 1

DPV repeatability / reproducibility test

Voltammetry

NiCu-CAT/GCE sensing electrode · Electrode

Five repeated modified-electrode tests for 40 uM paracetamol under optimised conditions.

Temperature: 298.15
Geometry: NiCu-CAT/GCE working electrode in three-electrode DPV setup.
Context: Composite NiCu-CAT/Nafion/GCE sensing electrode.
Measurement source: main p.7 · Discussion - Reproducibility, Stability and Interference · Figure 6a

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Repeatability relative standard deviationMarked as a best value within this paper	RSD = 1.01%	—	—	Text Exact Reported	main p.7 · Discussion - Reproducibility, Stability and Interference · Figure 6a

DPV stability test after storage in air

Voltammetry

NiCu-CAT/GCE sensing electrode · Electrode

40 uM paracetamol in 0.1 mol L^-1 PBS at pH 6.5 after storage in air for 7 and 30 days.

Temperature: 298.15
Atmosphere: Stored in air.
Geometry: NiCu-CAT/GCE working electrode in three-electrode DPV setup.
Context: Composite NiCu-CAT/Nafion/GCE sensing electrode.
Measurement source: main p.7 · Discussion - Reproducibility, Stability and Interference · Figure 6b; Supplementary Figure 5

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Response retention after storageMarked as a best value within this paper	more than 95.8% of original responses after 7 and 30 days	—	>	Text Approximate	main p.7 · Discussion - Reproducibility, Stability and Interference · Figure 6b; Supplementary Figure 5
Approximate response retention after 30 days from Figure 6b	approximately 96% at 30 days	—	visual estimate; about +/-2%	Visual Estimate Approximate	main p.6 · Figure 6 · Figure 6b

Differential pulse voltammetry stability traces from SI

Voltammetry

NiCu-CAT/GCE after air storage for 7-30 days · Electrode

Supplementary Figure 5 overlays DPV responses labelled 1 d, 7 d and 30 d, current vs potential around the paracetamol peak.

Temperature: 298.15
Atmosphere: Stored in air before measurement.
Geometry: NiCu-CAT/GCE working electrode in three-electrode DPV setup.
Context: Composite NiCu-CAT/Nafion/GCE sensing electrode after storage.
Measurement source: SI p.3 · Supplementary Figures · Supplementary Figure 5

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Approximate DPV peak current after 1 day	approximately 9.4 uA from Supplementary Figure 5	—	visual estimate; about +/-0.3 uA	Visual Estimate Approximate	SI p.3 · Supplementary Figures · Supplementary Figure 5
Approximate DPV peak current after 30 days	approximately 9.0 uA from Supplementary Figure 5	—	visual estimate; about +/-0.3 uA	Visual Estimate Approximate	SI p.3 · Supplementary Figures · Supplementary Figure 5
Approximate DPV peak current after 7 days	approximately 9.25 uA from Supplementary Figure 5	—	visual estimate; about +/-0.3 uA	Visual Estimate Approximate	SI p.3 · Supplementary Figures · Supplementary Figure 5

Supplementary Table 1 tablet recovery analysis

NiCu-CAT/GCE sensing electrode · Electrode

Four commercial tablet samples with nominal content 650 mg/tablet; detection amounts and recoveries tabulated.

Temperature: 298.15
Geometry: NiCu-CAT/GCE working electrode in three-electrode DPV setup.
Context: Composite NiCu-CAT/Nafion/GCE sensing electrode.
Measurement source: SI p.4 · Supplementary Table 1 · Supplementary Table 1

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Supplementary Table 1 sample 1 detected paracetamol amount	640 mg/tablet	—	—	SI Table Exact Reported	SI p.4 · Supplementary Table 1 · Supplementary Table 1
Supplementary Table 1 sample 1 recovery	98.46%	—	—	SI Table Exact Reported	SI p.4 · Supplementary Table 1 · Supplementary Table 1
Supplementary Table 1 sample 2 detected paracetamol amount	632 mg/tablet	—	—	SI Table Exact Reported	SI p.4 · Supplementary Table 1 · Supplementary Table 1
Supplementary Table 1 sample 2 recovery	97.23%	—	—	SI Table Exact Reported	SI p.4 · Supplementary Table 1 · Supplementary Table 1
Supplementary Table 1 sample 3 detected paracetamol amount	675 mg/tablet	—	—	SI Table Exact Reported	SI p.4 · Supplementary Table 1 · Supplementary Table 1
Supplementary Table 1 sample 3 recovery	103.8%	—	—	SI Table Exact Reported	SI p.4 · Supplementary Table 1 · Supplementary Table 1
Supplementary Table 1 sample 4 detected paracetamol amount	663 mg/tablet	—	—	SI Table Exact Reported	SI p.4 · Supplementary Table 1 · Supplementary Table 1
Supplementary Table 1 sample 4 recovery	102.0%	—	—	SI Table Exact Reported	SI p.4 · Supplementary Table 1 · Supplementary Table 1