Liu T.-Z., Hu R., Zhang X. et al. · Analytical Chemistry · 2016 · 12516-12523
Open a family to keep every result attached to its sample, method and conditions.
Paraphrased for this database from the authors’ stated interpretations — never quoted verbatim — and kept separate from reported measurements.
Cd-MOF-74 and ZIF-8 were presented as alternative MOF signal probes producing distinct DPV responses for Cd2+ and Zn2+ based systems.
Caveat: Only typical SI DPV traces are shown; no synthesis recipes or full assay performance data are reported for these alternative MOFs.
4 · Immunoassay Using MOF-Metal-Ion Probes · Figures S9 and S10 · Linked to 4 structured results
The proposed immunosensor is selective for CRP relative to CEA, HCG, glycine and glucose interferents.
Caveat: Interferent currents were estimated from Figure 7; exact numeric values were not tabulated.
6 · Analytical Performance · Figure 7 · Linked to 5 structured results
Under optimised conditions the Au-MOF/Pt-COF immunosensor detects CRP from 1 to 400 ng/mL with a 0.2 ng/mL detection limit.
Caveat: This is biosensing performance and should not be interpreted as intrinsic MOF transport performance.
6 · Analytical Performance · Figure 6 · Linked to 3 structured results
Au-MOFs serve both as antibody-supporting carriers and as Cu2+-containing signal tags for target CRP detection.
Caveat: Application performance depends on the full immunosensor construct, not the Au-MOF material alone.
5 · Characterization · Figure 2 · Linked to 4 structured results
The electrochemical signal is attributed to metal ions released from/corresponding to MOF frameworks rather than residual free ions adsorbed during synthesis.
Caveat: The mechanism is inferred from SI controls rather than from in situ structural measurements during each sensing run.
4 · Immunoassay Using MOF-Metal-Ion Probes · Figures S1-S8 · Linked to 6 structured results
Pt-COFs act as a high-electronic-conductivity electrode substrate; adding Pt-COFs to GCE decreases electrochemical impedance and improves relative electronic conductivity.
Caveat: The 400% value is reported in the main text and SI Figure S14 shows a redox-probe CV comparison; this is a relative electrochemical electron-transfer comparison, not an absolute conductivity measurement.
5 · Electrochemical Characterization of the Modified GC Electrode · Figure 3; Figure S14 · Linked to 6 structured results
Names and aliases are kept exactly within the paper’s own identity model.
| Material | Composition | Structure context | Source |
|---|---|---|---|
| Au-MOFsBrowse family: HKUST-1 / Cu₃(BTC)₂ | Au nanoparticles incorporated into HKUST-1Cu2+ HKUST-1 nodes plus Au nanoparticles · 1,3,5-benzenetricarboxylic acid | 3D · CompositeComposite Au-MOF nanoparticles; EDS used to confirm Au presence. | 5 · Characterization · Figure 2c,d; Figure S13 |
| Ab2-modified Au-MOF signal probeBrowse family: HKUST-1 / Cu₃(BTC)₂ | CRP antibody/BSA functionalised Au-HKUST-1Cu2+ HKUST-1 nodes plus Au nanoparticles · 1,3,5-benzenetricarboxylic acid | 3D · CompositeAntibody-functionalised Au-MOF nanoprobe used as the electrochemical metal-ion label. | 3 · Preparation of Signal-MOFs-Metal Ion Probes · Scheme 1 |
| Cd2+-exchanged HKUST-1 MOFsBrowse family: HKUST-1 / Cu₃(BTC)₂ | Cd2+-exchanged Cu-BTC / HKUST-1Cu2+ HKUST-1 coordination sites partly exchanged with Cd2+ · 1,3,5-benzenetricarboxylic acid | 3D · PristineIon-exchanged MOF confirmed by chromogenic test, TEM morphology change, XPS Cd 3d peaks, and DPV Cd2+ response. | 4 · Immunoassay Using MOF-Metal-Ion Probes · Figures S3-S6 |
| Cadmium-based MOFs (Cd-MOF-74) | Cd-MOF-74Cd2+ · not reported in this paper | 3D · PristineIdentified only as Cd-MOF-74 and evaluated by a typical DPV signal in the SI. | 4 · Immunoassay Using MOF-Metal-Ion Probes · Figure S9 |
| Covalent organic framework nanoparticles | imine COF from 1,4-diaminobenzene and 1,3,5-triformylbenzenenone · 1,4-diaminobenzene and 1,3,5-triformylbenzene condensed to imine-linked COF | 2D · PristineLayered crystalline COF with characteristic XRD peak at 5 degrees attributed to the (100) diffraction. | 2 · Experimental Section; Characterization · Figure 1 |
| HKUST-1 MOFsBrowse family: HKUST-1 / Cu₃(BTC)₂ | Cu-BTC / HKUST-1Cu2+ ions · 1,3,5-benzenetricarboxylic acid | 3D · PristineHKUST-1 identified by synthesis from CuSO4 and 1,3,5-benzenetricarboxylic acid and an XRD peak at 12 degrees. | 3 · Preparation of MOFs · Figure 2 |
| Platinum nanoparticle modified covalent organic frameworks | Pt NPs on imine COFPt nanoparticles hosted on COF surface; no metal nodes in COF backbone · imine COF from 1,4-diaminobenzene and 1,3,5-triformylbenzene | 2D · CompositePt nanoparticles anchored on layered COF; EDS used to confirm Pt presence. | 5 · Electrochemical Characterization of the Modified GC Electrode · Figure 3; Figure S14 |
| Zinc-based MOFs (ZIF-8)Browse family: ZIF-8 / Zn(mIm)₂ | ZIF-8Zn2+ · not reported in this paper | 3D · PristineIdentified only as ZIF-8 and evaluated by a typical DPV signal in the SI. | 4 · Immunoassay Using MOF-Metal-Ion Probes · Figure S10 |
Sample form, processing state and composition status define the context for measurements.
| Sample | Form and role | Processing and geometry | Source |
|---|---|---|---|
| Au-MOFs-Ab2 signal nanoproberesearch_0150__mat__mat_au_mof_ab2 | Powder · Composite Sample · Composite | Au-MOFs functionalised with CRP antibody at pH 9, blocked with BSA, washed, and resuspended in PBS. | 3 · Preparation of Signal-MOFs-Metal Ion Probes |
| Au-MOFs nanoparticlesresearch_0150__mat__mat_au_mof | Powder · Composite Sample · Composite | Cleaned HKUST-1 reacted with preformed citrate Au nanoparticles, then washed with ethanol and water. | 3 · Preparation of Au-MOFs |
| Cd2+-exchanged cleaned HKUST-1 MOFsresearch_0150__mat__mat_cd_exchanged_hkust1 | Powder · Model System · Doped | Cleaned MOFs dispersed in 10 mM Cd(NO3)2 aqueous solution for 24 h, then washed about 20 times before DPV/TEM/XPS tests. | 4 · Immunoassay Using MOF-Metal-Ion Probes · Figures S3-S6 |
| Cd-MOF-74 DPV signal-probe sampleresearch_0150__mat__mat_cd_mof74 | Powder · Model System · Pristine Framework | Not described; only a typical DPV signal is shown.glassy carbon electrode for DPV test (implied) | 11 · Supporting Information · Figure S9 |
| as-prepared COF nanoparticlesresearch_0150__mat__mat_cof | Powder · Pristine Control · Pristine Framework | Washed with DMF and THF, Soxhlet extracted with THF, and vacuum dried before Pt loading. | 2 · Preparation of Pt NPs Modified Covalent Organic Frameworks |
| Au-MOFs-Ab2-CRP/anti-CRP/Pt-COFs/GCE immunosensorresearch_0150__mat__mat_pt_cof | Electrode · Composite Sample · Composite | Pt-COF modified GCE carrying anti-CRP, CRP analyte, and Au-MOFs-Ab2 signal probe.glassy carbon electrode | 4 · Design Strategy · Scheme 1; Figure 3 |
| cleaned HKUST-1 MOFsresearch_0150__mat__mat_hkust1 | Powder · Pristine Control · Pristine Framework | Washed until no free Cu2+ was detected by the HAc/K4[Fe(CN)6] precipitation test; resuspended in methanol at 4 C. | 3 · Preparation of MOFs · Figure S1; Figure S2 |
| Pt-COFs nanomaterialresearch_0150__mat__mat_pt_cof | Powder · Target Sample · Composite | Pt nanoparticles reduced onto COF surface and resuspended in water. | 2 · Preparation of Pt NPs Modified Covalent Organic Frameworks |
| Pt-COFs modified glassy carbon electroderesearch_0150__mat__mat_pt_cof | Electrode · Composite Sample · Composite | Pt-COF/CHIT dispersion drop-cast on GCE and dried.glassy carbon electrode | 3 · Fabrication of Immunosensor · Scheme 1; Figure 3 |
| ZIF-8 DPV signal-probe sampleresearch_0150__mat__mat_zif8 | Powder · Model System · Pristine Framework | Not described; only a typical DPV signal is shown.glassy carbon electrode for DPV test (implied) | 12 · Supporting Information · Figure S10 |