Zhang S., Li Z., Wang Y. et al. · Microchemical Journal · 2025 · 114388
Open a family to keep every result attached to its sample, method and conditions.
Paraphrased for this database from the authors’ stated interpretations — never quoted verbatim — and kept separate from reported measurements.
The final CTF/CuxMn3-x(HITP)2 DNA-walker aptasensor detects CEA with a 2.91 fg mL-1 LOD and 1 pg mL-1 to 50 ng mL-1 range.
Caveat: Application result is from an electrochemical biosensor composite, not a standalone conductive-MOF transport device. SI Table S1 lists a conflicting this-work LOD of 0.065 pg mL-1, so both source-specific LOD values are retained in results.
8 · 3.4 Quantitative analysis of CEA · Fig. 4a-b · Linked to 6 structured results
The paper repeatedly attributes performance to high electronic/electron-transfer ability of CuxMn3-x(HITP)2, but it does not report a direct electrical conductivity, mobility, or thermoelectric measurement.
Caveat: Only EIS/CV/ECL evidence is extractable for transport-related behaviour.
9 · 4. Conclusion · Linked to 2 structured results
Mixed-valence Cu and Mn redox pairs in CuxMn3-x(HITP)2 accelerate persulfate radical generation and amplify CTF ECL emission.
Caveat: Mechanistic steps are inferred from ECL/CV/XPS evidence, not from direct radical quantification in the supplied text.
6 · 3.3 Feasibility analysis · Fig. 2d · Linked to 4 structured results
The CTF is a porous, highly crystalline imine-linked covalent triazine framework with AA eclipsed P6 structure.
Caveat: CTF is a COF/CTF rather than conductive MOF; included as emitter/control.
4 · 3.1 Structure analysis of CTF · Fig. 1; Fig. S1 · Linked to 5 structured results
CuxMn3-x(HITP)2 is a layered bimetallic semiconductive/conductive HITP MOF containing Cu and Mn and exhibiting mixed-valence metal sites.
Caveat: SI precursor line prints CoCl2.6H2O instead of a Cu salt; product assignment is supported by ICP/XPS text but synthesis precursor identity remains internally inconsistent.
SI text · S2 Characterizations of the CTF and CuxMn3-x(HITP)2 · Figs. S4-S6 · Linked to 5 structured results
The rHp/ssDNA double-stranded spacer weakens pi-pi stacking between CTF and CuxMn3-x(HITP)2, reducing quenching and turning the sensor into a signal-on ECL platform.
Caveat: Direct CTF/MOF spacing is not structurally quantified; claim is supported by ECL trends and PAGE assembly validation.
6 · 3.3 Feasibility analysis · Fig. S9; Fig. 3 · Linked to 3 structured results
CuxMn3-x(HITP)2 improves the aptasensor response by facilitating electron transfer and reducing charge-transfer resistance after coupling to the CTF electrode.
Caveat: No direct four-probe conductivity or mobility measurement is reported; transport evidence is electrochemical/EIS-based.
4 · 3.2 Construction of CTF-based ECL aptasensor · Fig. 2a-b · Linked to 3 structured results
Names and aliases are kept exactly within the paper’s own identity model.
| Material | Composition | Structure context | Source |
|---|---|---|---|
| covalent triazine framework | CTFNone · 4,4',4''-(1,3,5-triazine-2,4,6-triyl)tribenzaldehyde (TTB) and 4,4',4''-(1,3,5-triazine-2,4,6-triyl)trianiline (TTA) | 2D · PristineNitrogen-rich imine-linked covalent triazine framework; PXRD/Pawley refinement assigned hexagonal P6 with AA eclipsed stacking. | 4-5 · 3.1 Structure analysis of CTF · Fig. 1 |
| rHp/CuxMn3-x(HITP)2-MCH/ssDNA/CTF/AE aptasensor | rHp/CuxMn3-x(HITP)2-MCH/ssDNA/CTF on Au electrodeCu and Mn in CuxMn3-x(HITP)2 · HITP; TTB/TTA-derived CTF; ssDNA/rHp; MCH | unknown · CompositeComposite electrode in which a hybridised DNA spacer couples conductive CuxMn3-x(HITP)2 to CTF and amplifies ECL. | 3 · 2.2 Construction of the CTF-based ECL sensor · Scheme 1 |
| CuxMn3-x(HITP)2 | CuxMn3-x(HITP)2Cu and Mn mixed-metal nodes/sites · HITP: 2,3,6,7,10,11-hexaiminotriphenylene | 2D · PristineBimetallic semiconductive/conductive layered HITP MOF/scMOF, assigned by XRD peaks for (100), (200), and broad (001) reflections plus graphene-like Raman features. | SI text · S2 Characterizations of the CTF and CuxMn3-x(HITP)2 · Figs. S3-S6 |
| gold electrode | AEAu | unknown · Model SystemGold-disk electrode substrate/control for electrochemical and ECL tests. | SI text · S1.5 Pre-treatment of the bare AE |
| Hp-labelled CuxMn3-x(HITP)2 | Hp/CuxMn3-x(HITP)2Cu and Mn in CuxMn3-x(HITP)2 · HITP plus immobilised hairpin DNA (Hp) | 2D · CompositeGuest-loaded conductive MOF probe formed by soaking CuxMn3-x(HITP)2 with Hp DNA through pi-pi interaction. | SI text · S1.7 Immobilization of the Hp on the CuxMn3-x(HITP)2 |
Sample form, processing state and composition status define the context for measurements.
| Sample | Form and role | Processing and geometry | Source |
|---|---|---|---|
| bare gold electrode (AE)research_0171__mat__gold_electrode | Electrode · Model System · Model | Mechanically polished with 0.05 um aluminium oxide, sonicated in water, then electrochemically polished in 0.5 M H2SO4.gold electrode | SI text · S1.5 Pre-treatment of the bare AE |
| CTF/AEresearch_0171__mat__ctf | Electrode · Pristine Control · Composite | 10 uL CTF suspension drop-cast onto gold electrode and dried in air; optimal concentration later identified as 0.8 mg mL-1.gold electrode | 2-3 · 2.2 Construction of the CTF-based ECL sensor |
| purified CTF powderresearch_0171__mat__ctf | Powder · Pristine Control · Pristine Framework | Schiff-base CTF powder, yellow precipitate, centrifuged, rinsed, and vacuum dried. | 2 · 2.1 The preparation of CTF |
| CuxMn3-x(HITP)2/AEresearch_0171__mat__cu_mn_hitp | Electrode · Pristine Control · Composite | CuxMn3-x(HITP)2 deposited on AE for ECL-potential and comparison tests; exact deposition recipe not specified in text layer.gold electrode | SI text · S3 ECL performance of CTF and CuxMn3-x(HITP)2 · Fig. S10 |
| CuxMn3-x(HITP)2 powderresearch_0171__mat__cu_mn_hitp | Powder · Target Sample · Mixed Metal | Hydrothermal/solvothermal-style powder from metal chloride(s), MnCl2, HITP, water, and aqueous ammonia; vacuum dried. | SI text · S1.4 Preparation of CuxMn3-x(HITP)2 |
| rHp/CuxMn3-x(HITP)2-MCH/ssDNA/CTF/AEresearch_0171__mat__ctf_cu_mn_hitp_aptasensor | Electrode · Target Sample · Composite | CEA/Exo III DNA-walker product couples rHp/CuxMn3-x(HITP)2 to MCH/ssDNA/CTF/AE through rHp/ssDNA hybridisation.gold electrode | 3 · 2.2 Construction of the CTF-based ECL sensor · Scheme 1 |
| Hp-labelled CuxMn3-x(HITP)2 proberesearch_0171__mat__hp_cu_mn_hitp | Powder · Composite Component · Guest Loaded | CuxMn3-x(HITP)2 soaked with Hp DNA, centrifuged/washed, vacuum dried, and redispersed in PBS. | SI text · S1.7 Immobilization of the Hp on the CuxMn3-x(HITP)2 |
| MCH/ssDNA/CTF/AEresearch_0171__mat__ctf | Electrode · Composite Sample · Composite | ssDNA/CTF/AE soaked in 1 uM 6-mercapto-1-hexanol to block nonspecific adsorption sites; stored at 4 C.gold electrode | 3 · 2.2 Construction of the CTF-based ECL sensor |
| ssDNA/CTF/AEresearch_0171__mat__ctf | Electrode · Composite Sample · Composite | CTF/AE incubated with 10 uM ssDNA strand solution for 1 h and rinsed with PBS.gold electrode | 2-3 · 2.2 Construction of the CTF-based ECL sensor |