cMOF Evidence Base

Synthesis evidence

Copper-Based Two-Dimensional Conductive Metal-Organic Framework Thin Films for Ultrasensitive Detection of Perfluoroalkyls in Drinking Water

Roh H., Quill T.J., Chen G. et al. · ACS Nano · 2025 · 6332-6341

3 structured synthesis routes

Completeness describes how fully the route could be reconstructed from the main article and supporting information.

Complete recipeSource: Both

Route 1: Other

p007 / article p.6338 · Materials and Methods - MOF Film Growth · Figure 1; Figure S1

Metal precursorsCopper acetate, 1 mM in ethanol
Linker precursorsHHTP ligand, 0.1 mM in ethanol
Solventsethanol
AtmosphereAmbient during ligand exchange/dipping; annealed inside N2-filled glovebox
Temperatureambient during growth; 80 during annealing
Time0.5 h per growth cycle (10 min copper acetate plus 20 min HHTP); 2 h for 4 cycles; repeated to desired film thickness
Substrate orientationHydrophilic UV-ozone-treated ITO/glass/Si substrate surface; layer-by-layer on-surface growth
Work-upRinsed by dipping in fresh ethanol after copper acetate step and after HHTP ligand step; unreacted ligands rinsed off with fresh ethanol.
ActivationAnnealed at 80 C inside a N2-filled glovebox prior to characterisation.
Scalability contextAuthors report growth time roughly halved versus previous >1 h per cycle protocols by increasing metal-source and ligand concentrations; continuous film visible after 4 cycles.
Show 3 structured reagent records
RoleReagentAmount / concentrationSource
Metal Sourcecopper acetate1 mM in ethanolp007 / article p.6338 · Materials and Methods - MOF Film Growth · Figure 1; Figure S1
Linkerhexahydroxy triphenylene (HHTP)0.1 mM in ethanolp007 / article p.6338 · Materials and Methods - MOF Film Growth · Figure 1; Figure S1
SolventethanolNot specifiedp007 / article p.6338 · Materials and Methods - MOF Film Growth · Figure 1; Figure S1
Partial recipeSource: Main

Route 2: Other

p005 and p007 / article pp.6336 and 6338 · MOF-Based PFAS Sensing; Materials and Methods - Materials · Figure 3

Metal precursorsPreformed Cu-HHTP thin-film device
Solventsdistilled water and 0.1x PBS
AdditivesPFOA or PFOS analyte
Atmosphereambient aqueous exposure
Temperatureambient
Timenot reported for sensing exposure; PFOA stock stirred overnight before use
Substrate orientationMOF-covered channel fully immersed in contaminated water/PBS or aqueous sample dropped onto channel
Oxidant / reductantPFAS acts as oxidative analyte toward Cu-HHTP during sensing
Work-upPFOA dissolved in distilled water and stirred overnight; PFOS stock used as received; different PFAS concentrations obtained by dilution in PBS.
Scalability contextDevice can be used by dropping sample on the channel or by full immersion; authors state sensors offer readouts in minutes.
Show 3 structured reagent records
RoleReagentAmount / concentrationSource
OtherPFOAvarious concentrations; PFOA first dissolved in distilled water and stirred overnightp005 and p007 / article pp.6336 and 6338 · MOF-Based PFAS Sensing; Materials and Methods - Materials · Figure 3
OtherPFOS (40% in water)stock solution used as receivedp005 and p007 / article pp.6336 and 6338 · MOF-Based PFAS Sensing; Materials and Methods - Materials · Figure 3
Electrolytephosphate-buffered saline10x diluted to obtain 0.1x · 0.1x PBS for sensingp005 and p007 / article pp.6336 and 6338 · MOF-Based PFAS Sensing; Materials and Methods - Materials · Figure 3
Complete recipeSource: Main

Route 3: Other

p007 / article p.6338 · Materials and Methods - Substrate Treatment

Metal precursorsCommercial glass substrates with ITO stripes, Xin Yan Technology LTD pattern XY0040
Solventswater, acetone, isopropanol
Additivesacrylic tape to mask undesired growth areas
AtmosphereDried with pure N2; UV-ozone treated in air/ozone
Temperatureambient
Time0.25 h solvent sonication total plus 0.5 h UV-ozone treatment
Substrate orientationPatterned ITO stripes, 3 mm channel length; undesired areas covered with acrylic tape before film growth
Oxidant / reductantUV-ozone surface activation
Work-upSonicated successively in water, acetone, and isopropanol for 5 min each; dried with pure N2; immediately immersed into salt solution for film growth after ozone treatment.
Activation30 min UV-ozone lamp treatment to activate hydrophilic groups
Scalability contextBenign UV-ozone treatment avoids piranha treatment that tends to etch ITO and allows predefined growth areas.
Show 6 structured reagent records
RoleReagentAmount / concentrationSource
OtherGlass substrates with ITO-stripes (Xin Yan Technology LTD, pattern XY0040)Not specifiedp007 / article p.6338 · Materials and Methods - Substrate Treatment
Solventwater5 min sonicationp007 / article p.6338 · Materials and Methods - Substrate Treatment
Solventacetone5 min sonicationp007 / article p.6338 · Materials and Methods - Substrate Treatment
Solventisopropanol5 min sonicationp007 / article p.6338 · Materials and Methods - Substrate Treatment
OxidantUV-ozone lamp treatment30 minp007 / article p.6338 · Materials and Methods - Substrate Treatment
Additiveacrylic tapeused to cover undesired areasp007 / article p.6338 · Materials and Methods - Substrate Treatment