Zhang Y., Zhang Z., Rong S. et al. · Microchimica Acta · 2020 · 264
Open a family to keep every result attached to its sample, method and conditions.
Paraphrased for this database from the authors’ stated interpretations — never quoted verbatim — and kept separate from reported measurements.
The Au NPs@ZIF-8/OMC immunosensor detects CEA over 0.005-400 ng mL-1 with pg mL-1-level LOD and high reproducibility.
Caveat: Application is single-analyte CEA sensing; no multiplexed serum detection demonstrated.
8 · Conclusion · Linked to 4 structured results
The immunosensor gives acceptable recovery in diluted human serum and agrees with a commercial chemiluminescence immunoassay analyser.
Caveat: Real serum samples were diluted 100-fold; clinical sample comparison includes only four samples in the SI table.
8 · Real sample analysis · Table 2; Table S2 · Linked to 8 structured results
The reported optimum pH is inconsistent between the main text and SI.
Caveat: Main text says best sample pH value 7.4, while SI text states pH 7.0 was chosen.
6 · Optimization of experimental conditions · Fig. S4e · Linked to 2 structured results
Au nanoparticles supply antibody binding sites and promote conductivity, while OMC improves electron transfer, giving the Au@ZIF-8/OMC electrode the strongest DPV current-change response.
Caveat: The best DPV comparison values are visually estimated from Fig. 4c; the mechanistic assignment is author interpretation.
6 · Characteristics of different electrodes · Fig. 4c · Linked to 3 structured results
Au nanoparticle decoration does not alter the ZIF-8 crystal structure.
Caveat: XRD and microscopy are reported; no BET surface area or pore-size measurements are reported for the synthesised ZIF-8 in the main text or readable SI.
4 · Material characterization · Fig. 3a · Linked to 2 structured results
Pristine ZIF-8 behaves as a nonconducting layer on GCE and decreases the redox peak current.
Caveat: The statement is based on electrochemical response in ferri/ferrocyanide electrolyte, not a direct solid-state conductivity measurement.
4 · Characteristics of different electrodes · Fig. 4a · Linked to 1 structured result
Names and aliases are kept exactly within the paper’s own identity model.
| Material | Composition | Structure context | Source |
|---|---|---|---|
| Au NPs modified ZIF-8 nanoparticles (Au@ZIF-8)Browse family: ZIF-8 / Zn(mIm)₂ | Au nanoparticles on ZIF-8Zn(II) ZIF-8 nodes plus zero-valent Au nanoparticles · 2-methylimidazolate | 3D · CompositeAu nanoparticles decorated on crystalline ZIF-8 without changing the ZIF-8 XRD pattern or morphology. | 2 · Introduction |
| Au NPs@ZIF-8/OMC modified glassy carbon electrodeBrowse family: ZIF-8 / Zn(mIm)₂ | Au@ZIF-8 + OMC on GCEZn(II) ZIF-8 nodes plus zero-valent Au nanoparticles · 2-methylimidazolate | 3D · CompositeComposite electrode platform prepared by drop-casting OMC then Au@ZIF-8 onto GCE. | 3 · Fabrication of immunosensor |
| bare glassy carbon electrode | Cnone · none | unknown · Model SystemCommercial 3 mm diameter GCE control electrode. | 2 · Electrochemical measurements |
| CEA/anti-CEA/Au NPs@ZIF-8/OMC/GCE immunosensorBrowse family: ZIF-8 / Zn(mIm)₂ | CEA + anti-CEA + BSA + Au@ZIF-8 + OMC on GCEZn(II) ZIF-8 nodes plus zero-valent Au nanoparticles · 2-methylimidazolate | 3D · CompositeBiofunctionalised Au@ZIF-8/OMC/GCE electrode for CEA sensing. | 3 · Fabrication of immunosensor · Fig. 1 |
| ordered mesoporous carbon (OMC) | Cnone · none | unknown · DerivedPurchased ordered mesoporous carbon with ordered pores and short rod-like morphology. | 2 · Introduction |
| zeolitic imidazolate framework-8 (ZIF-8)Browse family: ZIF-8 / Zn(mIm)₂ | Zn(2-methylimidazolate)2Zn(II) nodes · 2-methylimidazolate | 3D · PristineSodalite-type ZIF-8 framework; XRD pattern consistent with simulated ZIF-8. | 2 · Introduction |
| ZIF-8/OMC modified glassy carbon electrodeBrowse family: ZIF-8 / Zn(mIm)₂ | ZIF-8 + OMC on GCEZn(II) ZIF-8 nodes · 2-methylimidazolate | 3D · CompositeComposite control electrode prepared from ZIF-8 and ordered mesoporous carbon on glassy carbon. | 5 · Characteristics of different electrodes · Fig. 4c |
Sample form, processing state and composition status define the context for measurements.
| Sample | Form and role | Processing and geometry | Source |
|---|---|---|---|
| anti-CEA/Au NPs@ZIF-8/OMC/GCEresearch_0508__mat__mat_immunosensor | Electrode · Target Sample · Composite | Anti-CEA immobilised on Au@ZIF-8/OMC/GCE for at least 12 h at 4 C; BSA blocked for 1 h.glassy carbon electrode | 3 · Fabrication of immunosensor |
| Au@ZIF-8/GCEresearch_0508__mat__mat_au_zif8 | Electrode · Composite Sample · Composite | Au@ZIF-8 deposited on GCE for electrochemical control.glassy carbon electrode | 5 · Characteristics of different electrodes · Fig. 4a-b |
| Au NPs@ZIF-8/OMC/GCEresearch_0508__mat__mat_au_zif8_omc_gce | Electrode · Target Sample · Composite | 3 uL OMC methanol dispersion on GCE followed by 3 uL Au@ZIF-8 methanol solution (2 mg mL-1), dried at room temperature.glassy carbon electrode | 3 · Fabrication of immunosensor |
| Au@ZIF-8 nanoparticlesresearch_0508__mat__mat_au_zif8 | Powder · Composite Component · Composite | ZIF-8 treated with chloroauric acid and reduced by NaBH4 in methanol; centrifuged, washed and vacuum-dried at 50 C. | 3 · Synthesis of Au@ZIF-8 nanoparticles |
| bare GCEresearch_0508__mat__mat_bare_gce | Electrode · Model System · Model | Polished and sonication-cleaned GCE control.glassy carbon electrode | 3 · Fabrication of immunosensor |
| CEA/anti-CEA/Au NPs@ZIF-8/OMC/GCEresearch_0508__mat__mat_immunosensor | Electrode · Target Sample · Composite | Anti-CEA/Au@ZIF-8/OMC/GCE exposed to CEA standards or serum samples and measured by DPV.glassy carbon electrode | 5 · Characteristics of different electrodes · Fig. 4a-b |
| ordered mesoporous carbonresearch_0508__mat__mat_omc | Powder · Composite Component · Derived Carbon | Purchased OMC dispersed in methanol before electrode drop-casting. | 2 · Materials |
| ZIF-8/GCEresearch_0508__mat__mat_zif8 | Electrode · Pristine Control · Pristine Framework | ZIF-8 deposited on GCE for electrochemical control; detailed deposition amount not separately reported.glassy carbon electrode | 5 · Characteristics of different electrodes · Fig. 4a-b |
| ZIF-8/OMC/GCEresearch_0508__mat__mat_zif8_omc_gce | Electrode · Composite Sample · Composite | ZIF-8 and OMC on GCE control used in DPV current-change comparison.glassy carbon electrode | 5 · Characteristics of different electrodes · Fig. 4c |
| ZIF-8 powderresearch_0508__mat__mat_zif8 | Powder · Pristine Control · Pristine Framework | Methanol-synthesised, centrifuged, methanol-washed and vacuum-dried at 50 C. | 3 · Synthesis of ZIF-8 |