Hu R., Zhong S., Liu H. et al. · Sensors and Actuators B: Chemical · 2024 · 134773
Open a family to keep every result attached to its sample, method and conditions.
Paraphrased for this database from the authors’ stated interpretations — never quoted verbatim — and kept separate from reported measurements.
The sensor response to PD-L1 is much larger than interferents and Cu-F/Hs retains more than 85% catalytic activity after 20 days.
Caveat: Selectivity and stability values are partly figure-read/threshold values rather than exact table values.
8 · 3.5 · Fig. 6C-D · Linked to 3 structured results
The Cu-F/Hs-assisted EIS sensor detects PD-L1 over 0.5-200 ng/mL with an LOD of 0.11 ng/mL in the Results section.
Caveat: Abstract gives 0.12 ng/mL, while Results and SI comparison table give 0.11 ng/mL.
8 · 3.5 · Fig. 6A-B · Linked to 5 structured results
Standard-addition tests in 10-fold diluted serum show recoveries between 98.50% and 108.80% with RSD below 7%.
Caveat: Serum matrix is diluted; number of biological replicates is not detailed in Table 1.
8 · 3.6 · Table 1 · Linked to 3 structured results
The paper reports electrochemical EIS/CV sensor responses but does not report intrinsic electrical conductivity, mobility, Seebeck coefficient, or porosity for Cu-F/Hs.
Caveat: Conductive-MOF database users should treat the transport evidence as application-level electrochemical response, not bulk transport physics.
6 · 3.2 · Fig. 3
Cu-F/Hs is a dual-ligand Cu-MOF constructed from Cu ions, phenylalanine, and histidine.
Caveat: No formula, porosity, surface area, or CIF/crystal structure file is provided; authors describe an amorphous crystal structure.
5 · 3.1 · Fig. 1; Fig. 2 · Linked to 4 structured results
Introducing histidine into Cu-F/Hs improves catalytic performance relative to Cu-Fs.
Caveat: Comparison is based on DA kinetic parameters; catalyst loadings and all assay details are not fully reproduced in the main text.
7 · 3.4 · Fig. 5B-C; Table S1 · Linked to 4 structured results
Phe is proposed to improve DA substrate affinity while His coordination to Cu mimics laccase active-site chemistry and improves catalytic activity.
Caveat: The affinity/catalysis interpretation is inferred from kinetic comparisons and literature rationale, not directly from binding thermodynamics.
3 · Introduction · Scheme 1 · Linked to 3 structured results
ODA promotes DA polymerisation and deposition, increasing the conductive PDA-mediated signal-down EIS response.
Caveat: Figure 4 impedance changes are visual estimates; the paper cautions that only four diamines were explored.
6 · 3.3 · Fig. 4 · Linked to 4 structured results
Conductive redox-active PDA products formed from DA decrease EIS and convert the sensor response from signal-up to signal-down.
Caveat: The conductivity of PDA is invoked through electrochemical response; no standalone conductivity value for PDA or Cu-F/Hs is reported.
6 · 3.2 · Fig. 3A-B · Linked to 4 structured results
Names and aliases are kept exactly within the paper’s own identity model.
| Material | Composition | Structure context | Source |
|---|---|---|---|
| Ab-Cu-F/Hs | Not specifiedCu ions in Cu-F/Hs · Phe and His ligands with PD-L1 antibody functionalisation | unknown · CompositeAntibody-functionalised Cu-F/Hs conjugate used in sandwich PD-L1 sensor. | 4 · 2.2 · Scheme 1B |
| Cu-F/Hs | Not specifiedCu ions · L-phenylalanine (Phe/F) and L-histidine (His/H) | unknown · PristineDual-ligand copper MOF; amorphous crystal structure with main XRD peaks assigned to (012) and (-104) planes and matched to simulated Cu-F/Hs pattern. | 3 · 2.2 · Scheme 1; Fig. 1 |
| Cu-Fs | Not specifiedCu ions · L-phenylalanine (Phe/F) | unknown · PristinePhenylalanine-only Cu-MOF control used for catalytic comparison. | 4 · 1.1 Synthesis of Cu-Fs · Table S1 |
| Cu-Hs | Not specifiedCu ions · L-histidine (His/H) | unknown · PristineHistidine-only copper MOF/reference material; synthesis not described in available text. | 7 · 3.4 · Fig. S3 |
| laccase | Not specified | unknown · Model SystemNatural enzyme reference for DA kinetic comparison. | 4 · Table S1 · Table S1 |
| PD-L1 aptamer/Ab-Cu-F/Hs/PDA gold electrode sensor | Not specifiedCu ions in Ab-Cu-F/Hs component · Phe/His in Cu-F/Hs; PD-L1 aptamer, antibody, MCH, PDA reaction product | unknown · CompositeComposite sandwich electrochemical biosensor on gold electrode. | 2 · Scheme 1 · Scheme 1B |
Sample form, processing state and composition status define the context for measurements.
| Sample | Form and role | Processing and geometry | Source |
|---|---|---|---|
| PD-L1 antibody functionalised Cu-F/Hsresearch_0730__mat__mat_ab_cu_f_hs | Unknown · Composite Sample · Composite | EDC/NHS-mediated antibody functionalisation, centrifuged and washed. | 4 · 2.2 |
| Cu-F/Hs with ODA in DA polymerisation mixtureresearch_0730__mat__mat_cu_f_hs | Unknown · Target Sample · Composite | Cu-F/Hs catalytic assay mixture containing ODA additive. | 6 · 2.5; 3.3 · Fig. 4; Fig. 5 |
| Cu-F/Hs powder/nanoparticlesresearch_0730__mat__mat_cu_f_hs | Powder · Target Sample · Pristine Framework | Washed with DMF and deionised water, dried, stored at 4 degC. | 3 · 2.2 · Fig. 1; Fig. 2 |
| Cu-Fs powder/nanoparticlesresearch_0730__mat__mat_cu_fs | Powder · Pristine Control · Pristine Framework | Washed with DMF and deionised water, dried, stored at 4 degC. | 4 · 1.1 Synthesis of Cu-Fs · Table S1 |
| Cu-Hs referenceresearch_0730__mat__mat_cu_hs | Unknown · Pristine Control · Pristine Framework | Not reported in available main/SI text. | 7 · 3.4 · Fig. S3 |
| laccase reference enzymeresearch_0730__mat__mat_laccase_reference | Model · Model System · Model | Literature/reference kinetic parameter comparison. | 4 · Table S1 · Table S1 |
| PD-L1 sandwich sensor on gold electroderesearch_0730__mat__mat_pd_l1_sensor | Electrode · Composite Sample · Composite | Gold electrode modified with PD-L1 Apt, MCH, PD-L1, Ab-Cu-F/Hs, then DA/ODA polymerisation.gold electrode | 4 · 2.4 · Scheme 1B |