Sensing Application — Modular conductive MOF-gated field-effect biosensor for sensitive discrimination on the small molecular scale

16 measurement groups · 53 results

Reported values remain attached to the sample, method, conditions, extraction quality and source location that produced them.

PCA under interferent and artificial cerebrospinal fluid

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

DA, NE and EP with 10^-5 M AA in 1x PBS and in artificial cerebrospinal fluid; n = 6.

Atmosphere: 1x PBS and alpha-CSF
Geometry: Two-element c-MOF extended-gate DGFET array
Context: biofluid application context
Measurement source: main p.8 · 3.5 Discrimination of catecholamines in biofluids · Fig. 5g,h

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
AA coexistence concentration for catecholamine discrimination	10^-5 M AA	—	—	Text Exact Reported	main p.8 · 3.5 Discrimination of catecholamines in biofluids · Fig. 5g
Biofluid/interferent PCA discrimination	non-overlapping and distinguished patterns with AA and clear identification in alpha-CSF	—	—	Qualitative Qualitative	main p.8 · 3.5 Discrimination of catecholamines in biofluids · Fig. 5g,h
PCA PC1 variance with AA coexistence	82.17%	—	—	Figure Axis Approximate	main p.7 image · Fig. 5 visual read · Fig. 5g
PCA PC2 variance with AA coexistence	17.64%	—	—	Figure Axis Approximate	main p.7 image · Fig. 5 visual read · Fig. 5g
PCA PC1 variance in artificial CSF	76.75%	—	—	Figure Axis Approximate	main p.7 image · Fig. 5 visual read · Fig. 5h
PCA PC2 variance in artificial CSF	22.87%	—	—	Figure Axis Approximate	main p.7 image · Fig. 5 visual read · Fig. 5h

DGFET dopamine response of bare electrode

Bare SnO2/ITO extended-gate electrode · Electrode

DA in 1x PBS; bare electrode control.

Atmosphere: 1x PBS
Geometry: Bare SnO2/ITO extended-gate DGFET
Context: bare control dopamine response
Measurement source: main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. S12

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Bare electrode dopamine response	no significant DeltaVG	—	—	Qualitative Qualitative	main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. S12
Bare electrode NE and EP response	no response to bare electrode	—	—	Qualitative Qualitative	main p.7 · 3.4 Discrimination of neurotransmitters · Fig. S21

DGFET ID-VG response to dopamine and DeltaVG extraction

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

DA in 1x PBS, 10^-11 to 10^-3 M; 10 min immersion; DeltaVG at 10^-9 A.

Atmosphere: 1x PBS
Geometry: Cu3HHTP2-coated extended-gate DGFET
Context: HTP dopamine sensing
Measurement source: main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. 4b

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Dopamine concentration range measured	10^-11 M to 10^-3 M	—	—	Text Range	main p.4 · 2.6 Measurement setup
HTP dopamine response trend	DeltaVG proportionally increased with DA concentration	—	—	Qualitative Qualitative	main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. 4b
Reference current for voltage-shift extraction	10^-9 A	—	—	Text Exact Reported	main p.4 · Fig. 1 caption · Fig. 1d

DGFET ID-VG response to dopamine and DeltaVG extraction

TCP sensor: Cu2TCPP thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

DA in 1x PBS, 10^-11 to 10^-3 M; 10 min immersion; DeltaVG at 10^-9 A.

Atmosphere: 1x PBS
Geometry: Cu2TCPP-coated extended-gate DGFET
Context: TCP dopamine sensing
Measurement source: main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. 4c

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
TCP dopamine response trend	DeltaVG proportionally increased with DA concentration	—	—	Qualitative Qualitative	main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. 4c

DGFET DeltaVG response to interfering substances

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

HTP and TCP response to 10^-5 M AA, CaCl2, MgCl2 and glucose in 1x PBS.

Atmosphere: 1x PBS
Geometry: Two-element c-MOF extended-gate DGFET array
Context: interferent selectivity context
Measurement source: main p.8 · 3.5 Discrimination of catecholamines in biofluids · Fig. 5f; Figs. S27-S29

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Interferent concentration tested	10^-5 M	—	—	Text Exact Reported	main p.8 · 3.5 Discrimination of catecholamines in biofluids · Fig. 5f
AA/CaCl2/MgCl2/glucose interferent response	did not show significant electric responses	—	—	Qualitative Qualitative	main p.8 · 3.5 Discrimination of catecholamines in biofluids · Fig. 5f; Figs. S27-S29

LOD and linear detection range analysis

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

LOD calculated as concentration at signal equal to three standard deviations above background; linear ranges from PCA score plots.

Atmosphere: 1x PBS
Geometry: Two-element c-MOF extended-gate DGFET array
Context: HTP/TCP array
Measurement source: SI rendered p.23 · Supplementary Figures and Tables · Fig. S22

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
DA linear detection range	10^-8 M to 10^-3 M	—	—	Text Range	main p.8 · 3.4 Discrimination of neurotransmitters · Fig. S25
EP linear detection range	10^-7 M to 10^-3 M	—	—	Text Range	main p.8 · 3.4 Discrimination of neurotransmitters · Fig. S25
NE linear detection range	10^-8 M to 10^-3 M	—	—	Text Range	main p.8 · 3.4 Discrimination of neurotransmitters · Fig. S25
DA LOD on HTP sensor	1.74 nM	—	—	Figure Axis Rounded Reported	SI rendered p.23 · Supplementary Figures and Tables · Fig. S22
DA LOD on TCP sensor	1.95 nM	—	—	Figure Axis Rounded Reported	SI rendered p.23 · Supplementary Figures and Tables · Fig. S22
EP LOD on HTP sensor	1.66 nM	—	—	Figure Axis Rounded Reported	SI rendered p.23 · Supplementary Figures and Tables · Fig. S22
EP LOD on TCP sensor	1.88 nM	—	—	Figure Axis Rounded Reported	SI rendered p.23 · Supplementary Figures and Tables · Fig. S22
NE LOD on HTP sensor	1.52 nM	—	—	Figure Axis Rounded Reported	SI rendered p.23 · Supplementary Figures and Tables · Fig. S22
NE LOD on TCP sensor	1.55 nM	—	—	Figure Axis Rounded Reported	SI rendered p.23 · Supplementary Figures and Tables · Fig. S22

Long-term stability of HTP dopamine response

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

HTP response toward 10^-5 M DA in 1x PBS after 50 days in atmosphere.

Atmosphere: 1x PBS; atmosphere storage
Geometry: Cu3HHTP2 extended-gate DGFET
Context: HTP long-term application stability
Measurement source: main p.8 · 3.5 Discrimination of catecholamines in biofluids · Fig. S30

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
HTP long-term stability duration	50 days in atmosphere	—	—	Text Exact Reported	main p.8 · 3.5 Discrimination of catecholamines in biofluids · Fig. S30
HTP DA-response retention at 50 daysMarked as a best value within this paper	~103% of day-0 response	—	—	Figure Axis Approximate	SI rendered p.31 · Supplementary Figures and Tables · Fig. S30

DGFET dopamine response comparing HTP-Co and HTP

HTP-Co sensor: Co3HHTP2 thin film-modified electrode · Electrode

10^-3 M DA; comparison of Co3HHTP2 and Cu3HHTP2 films.

Geometry: c-MOF-coated extended-gate DGFET
Context: Co3HHTP2 control versus Cu3HHTP2
Measurement source: main p.7 · 3.3 c-MOF thin films as active sensing layer · Fig. 4f

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
HTP-Co DA response reduction relative to HTP	83.2% decrease at 10^-3 M DA	—	—	Text Exact Reported	main p.7 · 3.3 c-MOF thin films as active sensing layer · Fig. 4f

DGFET DeltaVG concentration response for neurotransmitters

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

HTP sensor; DA, NE, EP and 5-HT in 1x PBS after 10 min incubations.

Atmosphere: 1x PBS
Geometry: Cu3HHTP2 extended-gate DGFET
Context: HTP neurotransmitter sensing
Measurement source: main p.7 · 3.4 Discrimination of neurotransmitters · Fig. 5a; Fig. S20

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
HTP DA DeltaVG at 10^-3 M	~1100 mV	—	~100 mV visual	Visual Estimate Approximate	main p.7 image · Fig. 5 visual read · Fig. 5a,b
HTP EP DeltaVG at 10^-3 M	~1320 mV	—	~100 mV visual	Visual Estimate Approximate	main p.7 image · Fig. 5 visual read · Fig. 5a,b
HTP NE DeltaVG at 10^-3 M	~1050 mV	—	~100 mV visual	Visual Estimate Approximate	main p.7 image · Fig. 5 visual read · Fig. 5a,b
5-HT response on c-MOF sensors	negligible electrical responses	—	—	Qualitative Qualitative	main p.7 · 3.4 Discrimination of neurotransmitters · Fig. 5a,b

Principal component analysis of HTP/TCP sensor array response

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

Two-element HTP/TCP array; 10^-5 M biogenic amines in 1x PBS; n = 20.

Atmosphere: 1x PBS
Geometry: Two-element c-MOF extended-gate DGFET array
Context: Cu3HHTP2 and Cu2TCPP sensing layers
Measurement source: main p.7-8 · 3.4 Discrimination of neurotransmitters · Fig. 5e; Fig. S26

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Catecholamine discrimination lower demonstrated concentrationMarked as a best value within this paper	up to 10^-8 M	—	—	Text Exact Reported	main p.8 · 3.4 Discrimination of neurotransmitters · Fig. S26
PCA discrimination at 10^-5 M biogenic amines	non-overlapping discriminated patterns for all subjects	—	—	Qualitative Qualitative	main p.8 · 3.4 Discrimination of neurotransmitters · Fig. 5e
PCA principal component 1 variance at 10^-5 M biogenic amines	60.83%	—	—	Figure Axis Approximate	main p.7 image · Fig. 5 visual read · Fig. 5e
PCA principal component 2 variance at 10^-5 M biogenic amines	38.66%	—	—	Figure Axis Approximate	main p.7 image · Fig. 5 visual read · Fig. 5e

DGFET DeltaVG concentration response for neurotransmitters

TCP sensor: Cu2TCPP thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

TCP sensor; DA, NE, EP and 5-HT in 1x PBS after 10 min incubations.

Atmosphere: 1x PBS
Geometry: Cu2TCPP extended-gate DGFET
Context: TCP neurotransmitter sensing
Measurement source: main p.7 · 3.4 Discrimination of neurotransmitters · Fig. 5b; Fig. S20

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
TCP response reduction for DA relative to HTP at 10^-3 M	13.4%	—	—	Text Exact Reported	main p.7 · 3.4 Discrimination of neurotransmitters · Fig. S23
TCP DA DeltaVG at 10^-3 M	~950 mV	—	~100 mV visual	Visual Estimate Approximate	main p.7 image · Fig. 5 visual read · Fig. 5a,b
TCP response reduction for EP relative to HTP at 10^-3 MMarked as a best value within this paper	67.9%	—	—	Text Exact Reported	main p.7 · 3.4 Discrimination of neurotransmitters · Fig. S23
TCP EP DeltaVG at 10^-3 M	~430 mV	—	~100 mV visual	Visual Estimate Approximate	main p.7 image · Fig. 5 visual read · Fig. 5a,b
TCP response reduction for NE relative to HTP at 10^-3 M	39.7%	—	—	Text Exact Reported	main p.7 · 3.4 Discrimination of neurotransmitters · Fig. S23
TCP NE DeltaVG at 10^-3 M	~650 mV	—	~100 mV visual	Visual Estimate Approximate	main p.7 image · Fig. 5 visual read · Fig. 5a,b

DGFET dopamine response in different PBS strengths

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

HTP sensor; DA measured in 0.01x, 0.1x and 1x PBS over 10^-7 to 10^-3 M.

Atmosphere: PBS solutions
Geometry: Cu3HHTP2-coated extended-gate DGFET
Context: HTP Debye-screening test
Measurement source: main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. 4e

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
DA response under PBS strength variation	no significant decrease from 0.01x to 1x PBS over 10^-7 to 10^-3 M	—	—	Qualitative Qualitative	main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. 4e

DGFET threshold voltage shift versus pH

Bare SnO2/ITO extended-gate electrode · Electrode

Buffer solutions pH 4, 7 and 10; DeltaVG measured at reference current 10^-9 A; n = 3.

Atmosphere: aqueous buffer
Geometry: Bare extended-gate DGFET
Context: bare control pH response
Measurement source: main p.5 · 3.2 Electrical characteristics · Fig. 3c; Fig. S10

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Bare electrode pH sensitivityMarked as a best value within this paper	966.0 mV/pH	—	—	Text Exact Reported	main p.5 · 3.2 Electrical characteristics · Fig. 3c

DGFET threshold voltage shift versus pH

HTP sensor: Cu3HHTP2 thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

Buffer solutions pH 4, 7 and 10; DeltaVG measured at reference current 10^-9 A; n = 3.

Atmosphere: aqueous buffer
Geometry: Extended-gate DGFET
Context: HTP pH response
Measurement source: main p.5 · 3.2 Electrical characteristics · Fig. 3c; Fig. S10

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
HTP pH sensitivity	782.1 mV/pH	—	—	Text Exact Reported	main p.5 · 3.2 Electrical characteristics · Fig. 3c

DGFET threshold voltage shift versus pH

TCP sensor: Cu2TCPP thin film on SnO2/ITO extended gate, 10 growth cycles · Electrode

Buffer solutions pH 4, 7 and 10; DeltaVG measured at reference current 10^-9 A; n = 3.

Atmosphere: aqueous buffer
Geometry: Extended-gate DGFET
Context: TCP pH response
Measurement source: main p.5 · 3.2 Electrical characteristics · Fig. 3c; Fig. S10

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
TCP pH sensitivity	785.2 mV/pH	—	—	Text Exact Reported	main p.5 · 3.2 Electrical characteristics · Fig. 3c

DGFET dopamine DeltaVG versus Cu3HHTP2 growth cycles/thickness

Cu3HHTP2 thickness series on extended gate, 5/10/15/20 growth cycles · Electrode

10^-3 M DA in 1x PBS; Cu3HHTP2 films with varied growth cycles.

Atmosphere: 1x PBS
Geometry: Cu3HHTP2-coated extended-gate DGFET
Context: pristine c-MOF thickness series
Measurement source: main p.6 · 3.3 c-MOF thin films as active sensing layer · Fig. 4d; Fig. S17

Property	Reported value	Normalised value	Uncertainty	Origin and quality	Source
Cu3HHTP2-0C DeltaVG for 10^-3 M DA	~0 mV	—	—	Visual Estimate Approximate	main p.6 image · Fig. 4 visual read · Fig. 4d
Cu3HHTP2-10C DeltaVG for 10^-3 M DAMarked as a best value within this paper	~1100 mV	—	—	Visual Estimate Approximate	main p.6 image · Fig. 4 visual read · Fig. 4d
Cu3HHTP2-10C AFM thickness	18.2 +/- 3.3 nm	—	+/- 3.3 nm	Figure Axis Rounded Reported	SI rendered p.4 · Supplementary Figures and Tables · Fig. S3a
Cu3HHTP2-15C DeltaVG for 10^-3 M DA	~1000 mV	—	—	Visual Estimate Approximate	main p.6 image · Fig. 4 visual read · Fig. 4d
Cu3HHTP2-15C AFM thickness	53.7 +/- 9.8 nm	—	+/- 9.8 nm	Figure Axis Rounded Reported	SI rendered p.16 · Supplementary Figures and Tables · Fig. S15
Cu3HHTP2-20C DeltaVG for 10^-3 M DA	~930 mV	—	—	Visual Estimate Approximate	main p.6 image · Fig. 4 visual read · Fig. 4d
Cu3HHTP2-20C AFM thickness	85.9 +/- 16.9 nm	—	+/- 16.9 nm	Figure Axis Rounded Reported	SI rendered p.16 · Supplementary Figures and Tables · Fig. S15
Cu3HHTP2-5C DeltaVG for 10^-3 M DA	~700 mV	—	—	Visual Estimate Approximate	main p.6 image · Fig. 4 visual read · Fig. 4d
Cu3HHTP2-5C AFM thickness	5.4 +/- 2.0 nm	—	+/- 2.0 nm	Figure Axis Rounded Reported	SI rendered p.16 · Supplementary Figures and Tables · Fig. S15