Complete recipeSource: Main
Route 1: Liquid Liquid Interface
2 · Experimental Section - Synthesis
Metal precursorsCdI2 (0.074 g, 0.2 mmol)
Linker precursorsisoniazid/INH (0.028 g, 0.2 mmol); neutralised 2-mercaptobenzoic acid/2-MBA (0.031 g, 0.2 mmol)
Solventswater (2 mL); 1:1 v/v DMF-H2O buffer solution (2 mL); methanol (10 mL); ethanol (2 mL)
AdditivesEt3N used to neutralise 2-MBA
Atmosphereair; authors state the oxidative in situ disulfide-bond generation occurs in the presence of air
Temperatureroom temperature not explicitly stated
Time168
Oxidant / reductantAir/O2 acts as oxidant for in situ oxidation of thiol groups to disulfide.
Work-upPrism-shaped yellow crystals isolated after 1 week; no washing protocol reported for crystals.
Activationnone reported
Scalability contextSmall solution-layering crystallisation; 43 mg product, 75% yield.
Show 8 structured reagent records
| Role | Reagent | Amount / concentration | Source |
|---|---|---|---|
| Metal Source | CdI2 | 0.074 g, 0.2 mmol | 2 · Experimental Section - Synthesis |
| Linker | isoniazid (INH) | 0.028 g, 0.2 mmol | 2 · Experimental Section - Synthesis |
| Linker | 2-MBA (2-mercaptobenzoic acid), neutralized by Et3N | 0.031 g, 0.2 mmol | 2 · Experimental Section - Synthesis |
| Solvent | water | 2 mL | 2 · Experimental Section - Synthesis |
| Solvent | 1:1 (v/v) DMF-H2O buffer solution | 2 mL | 2 · Experimental Section - Synthesis |
| Solvent | methanol | 10 mL | 2 · Experimental Section - Synthesis |
| Solvent | ethanol | 2 mL | 2 · Experimental Section - Synthesis |
| Base | Et3N | not reported | 2 · Experimental Section - Synthesis |