Application of conductive MOFs in chemiresistive sensors
5-6Connects gas and VOC sensing to adsorption, redox reactions, binding-site accessibility, morphology, film deposition, and interface management.
Relevance: Core · 5 · Gas sensors
Lingli Qu, Yiwen Xu, Weikang Cui et al. · Analytica Chimica Acta · 2025
To review conductive MOF materials, construction and integration strategies, composite functionalisation, and sensing mechanisms across electrochemical, chemiresistive, FET, optical, photoelectrochemical, and potentiometric sensor formats.
The review’s argument is preserved as a navigable set of section summaries.
Connects gas and VOC sensing to adsorption, redox reactions, binding-site accessibility, morphology, film deposition, and interface management.
Relevance: Core · 5 · Gas sensors
States gaps in conductivity measurement consistency, synthesis scalability, morphology control, water stability, target interactions, and redox-active ligand development.
Relevance: Core · 9 · Conclusions and perspectives
Summarises conductivity as a function of carrier density and mobility, with band, hopping, through-bond, through-space, and guest-assisted routes.
Relevance: Core · 1 · Construction strategies for conductive MOFs
Reviews drop casting, hydrothermal/direct growth, liquid-phase epitaxy, and microfluidic or solution-shearing approaches for integrating conductive MOF films with devices.
Relevance: Core · 2 · Methods for the integration of 2D MOFs into electronic devices
Explains conductive MOFs as FET channels and electrochemical electrode materials, highlighting substrate contact, anisotropic transport, pore screening, and interference limits.
Relevance: Core · 6 · Application of conductive MOFs in field-effect transistor (FET) sensors
Surveys composites with metal nanoparticles, enzymes, aptamers, and graphene as ways to improve conductivity, selectivity, sensitivity, and structural support.
Relevance: Core · 4 · Functionalization strategies of conductive MOFs
Defines MOFs and frames conventional MOFs as often insulating because ligand spacing limits pi-pi stacking and low-energy charge transfer paths.
Relevance: Core · 1 · Introduction
Organises common sensing-relevant conductive MOFs by ligand families including HHTP/CAT, HITP, HAB, TCPP, and phthalocyanine frameworks.
Relevance: Core · 2 · Conductive MOFs commonly used for sensing
Covers ECL/FL, PEC, and ion-selective sensing where conductivity, porosity, channel size, ion-electron conversion, and photoactive ligands matter.
Relevance: Supporting · 9 · Application of conductive MOFs for potentiometric ion detection
Classification systems are attributed to this review and are not treated as a global material registry.
The review presents through-space pi-stacking, through-bond metal-ligand covalency, and guest-mediated conductive pathways as major routes to improve MOF conductivity.
Categories: through-space approach · through-bonding approach · guest or redox-active species in pores
1 · Introduction; Construction strategies for conductive MOFs · Fig. 2
Composite classes are presented as ways to improve conductivity, selectivity, sensing chemistry, and mechanical or structural support.
Categories: metal nanoparticles · enzymes · aptamers · graphene
4 · Functionalization strategies of conductive MOFs
The review frames conductive MOF charge conduction in terms of band-like and hopping mechanisms, with orbital overlap improving charge mobility.
Categories: band theory · hopping processes
1 · Construction strategies for conductive MOFs
The review groups processing approaches by whether MOFs are deposited after synthesis, directly grown on substrates, epitaxially oriented, or formed in scalable microfluidic/shearing platforms.
Categories: drop casting · hydrothermal synthesis · liquid phase epitaxial growth · microfluidic technology · solution shearing
2-3 · Methods for the integration of 2D MOFs into electronic devices
The review uses ligand family as the primary material organisation for sensing-relevant conductive MOFs.
Categories: HHTP/CAT · HITP · HAB · TCPP/porphyrin · phthalocyanine
2 · Conductive MOFs commonly used for sensing
The review classifies applications by transduction mechanism and associates each mode with different roles for charge transport, porosity, redox chemistry, or ion-electron conversion.
Categories: chemiresistive · electrochemical and cyclic voltammetry · field-effect transistor · electrochemiluminescence and fluorescence · photoelectrochemical · potentiometric ion detection
10 · Figures and tables · Fig. 1
Review-defined families retain their representative materials and conduction descriptions.
Hybrid materials combining conductive MOFs with graphene, graphene oxide, or reduced graphene oxide sheets.
Conduction: Graphene supports can provide high carrier mobility and prevent MOF aggregation, but defects, oxidation, roughness, and stacking can increase resistance.
Representative materials: GO/YbHHTP · Cu-CAT@rGO · GO/PDDA/Co3(HITP)2 · Cu-(HHTP)(THQ)@rGO
Nodes / linkers: Yb · Cu · Co · HHTP · CAT · THQ · HITP
5 · Conductive MOF/graphene composites
Hexaaminobenzene-based 2D MOFs, including crystalline and amorphous or missing-linker variants.
Conduction: Small HAB ligands support high-density redox-active frameworks, while defect sites can introduce water-transport mechanisms for humidity sensing.
Representative materials: Ni-HAB · aNi-HAB · Co-HAB · Cu3HIB2
Nodes / linkers: Ni · Co · Cu · HAB · HIB
2 · Benzene-based MOFs
Triphenylene catecholate frameworks based on HHTP or CAT-type oxygen donors, often paired with Cu, Ni, or mixed metals.
Conduction: Redox-active catecholate linkers and metal nodes promote charge delocalisation, pi-pi stacking between layers, and high charge density.
Representative materials: Cu3(HHTP)2 · Ni3(HHTP)2 · Ni-CAT-1 · NiCu-CAT
Nodes / linkers: Cu · Ni · Co · Fe · HHTP · CAT
2 · Hexahydroxytriphenyl MOFs
Hexaiminotriphenylene frameworks where imine/amino nitrogen donors coordinate transition metals in planar honeycomb sheets.
Conduction: The review highlights Ni-N d-pi bonding, D4h coordination, and stacked 2D porous lattices as enabling electron transfer.
Representative materials: Ni3(HITP)2 · Cu3(HITP)2 · Co3(HITP)2 · CoxNi3-x(HITP)2
Nodes / linkers: Ni · Cu · Co · HITP
2 · Hexaiminotriphenylene MOFs · Fig. 3
Conductive frameworks built from metal phthalocyanine units, commonly with Cu linkages and Co or Ni macrocycle centres.
Conduction: Large conjugated MPc backbones and peripheral donor groups promote planar coordination, electronic communication, and high intrinsic conductivity.
Representative materials: MPc-Cu-X · CoPc-O8-Cu · NiPc-O8-Cu · NiPc-Cu-MOF · CoPc-Cu-MOF
Nodes / linkers: Co · Ni · Cu · metal phthalocyanine · MPc
2 · Phthalocyanine-based MOFs · Fig. 6
Porphyrin-based MOFs containing aromatic macrocycles and carboxyl groups, often modified with metals or enzymes.
Conduction: Aromatic porphyrin ligands support photoelectric, catalytic, adsorption, and optical responses; metal centres can tune electronic conduction and catalysis.
Representative materials: Cu-TCPP · Cu-TCPP(Fe) · Cu2TCPP · Tyr@Cu-TCPP
Nodes / linkers: Cu · Fe · Pd · Yb · TCPP · porphyrin
2 · Tetraphenylporphyrin MOFs
Review-level synthesis principles remain separate from primary-study recipes.
Conductive MOFs are used as protective, conductive, high-area scaffolds for enzymes or aptamers that provide molecular recognition.
Claimed effects: Improves biological stability, specificity, and electrochemical signal transduction for biosensing.
Controlling variables: recognition element · MOF surface chemistry · immobilisation stability · biological sample matrix · electron-transfer hindrance
Representative materials: Tyr@Cu-TCPP · CoxNi3-x(HITP)2 · Ru-MOF
Caveat: Aptamer screening, ligand stability, real-sample reliability, and rapid onsite pathogen detection remain immature.
4-5 · Composites of conductive MOFs/enzymes; Conductive MOF/aptamer composites
Preformed MOF material is dispersed and applied to electrodes or substrates as a low-barrier route to electronic sensors.
Claimed effects: Fast and simple integration, but prone to insoluble-material problems, crystallinity changes, structural damage, uneven film thickness, and limited mechanical stability.
Controlling variables: solvent dispersion · drop volume · film uniformity · substrate electrode geometry
Representative materials: Cu3(HHTP)2 · Cu3(HITP)2 · Ni3(HITP)2
Caveat: The review treats this as convenient but inferior for controlled thin-film transport and reproducible device contact.
3 · Drop casting method
Graphene-family supports are combined with conductive MOFs to promote electron transfer, mechanical support, active-site exposure, and anti-aggregation.
Claimed effects: Can improve conductivity and sensor response by coupling high carrier mobility supports with porous MOF activity.
Controlling variables: graphene oxidation state · stacking and aggregation · polymer intercalation · surface roughness · reduction conditions
Representative materials: GO/YbHHTP · GO/PDDA/Co3(HITP)2 · Cu-CAT@rGO
Caveat: Stacking, grain boundaries, defects, oxide traps, and roughness can reduce performance and require optimisation.
5 · Conductive MOF/graphene composites
MOF crystals or films are grown under solvothermal or hydrothermal conditions, sometimes directly on device substrates or supports.
Claimed effects: Improves crystallisation and can form uniform MOF crystals or integrated films; direct integration can improve contact and sensing performance.
Controlling variables: temperature · pressure · reaction medium · substrate chemistry · reaction-system parameters
Representative materials: GO/YbHHTP · Ni/Co(HHTP)MOF/CC · Ni3(HITP)2
Caveat: Conventional post-synthesis dripping is still common, and direct integration examples are fewer.
3 · Hydrothermal synthesis
Chemically anchored substrates are used to template oriented MOF layers with controlled thickness and crystallographic orientation.
Claimed effects: Produces consistent coatings and oriented interfaces that can improve analyte detection and reduce interference.
Controlling variables: substrate functional groups · crystal orientation · film thickness · surface chemistry
Representative materials: Cu3(HHTP)2 · conductive MOF nanofilms
Caveat: Requires substrate- and MOF-specific design; sequential deposition can be slow and automation is needed.
3 · Liquid phase epitaxial growth
Metal nanoparticles or bimetallic centres are combined with conductive MOFs to improve electron transfer, adsorption, catalytic activity, and sensor amplification.
Claimed effects: Enhances sensitivity, stability, catalytic activity, and controllability relative to pure conductive MOFs.
Controlling variables: metal identity · loading · dispersion · active-site exposure · metal ratio
Representative materials: Pt@Cu3(HHTP)2 · Au/Pt-loaded Co3(HITP)2 · Ni/Co(HHTP)MOF/CC
Caveat: Gas-sensor examples still face thin-film fabrication burdens, selectivity issues, high metal loading, and nanoenzyme design challenges.
4 · Composites of conductive MOFs/metal materials
Microfluidic control and meniscus or solution shearing are combined to form large-area, thin, controlled conductive MOF films and catalyst-containing films.
Claimed effects: Addresses directional crystal growth, thickness control, high-throughput manufacturing, and catalytic enhancement for gas sensing.
Controlling variables: meniscus movement · heated substrate · microchannel geometry · nanocatalyst dispersion · post-synthesis rapid crystallisation
Representative materials: Pt@Cu3(HHTP)2 · Ni3(HITP)2
Caveat: Large MOF dimensions, catalyst integration, and scalable high-quality film formation remain problematic.
3 · Microfluidic technology · Fig. 7
Conductive MOFs are self-assembled directly on fibres, textiles, or patterned polymer/electrode structures to create chemiresistive devices.
Claimed effects: Can maintain flexible textile function, simplify processing, provide direct electrode contact, and enable gas detection in wearable or patterned formats.
Controlling variables: fibre surface · template growth solution · electrode pattern · washing and regeneration
Representative materials: Ni3(HITP)2 · Ni3(HHTP)2
Caveat: The review does not resolve long-term device stability across complex operating environments.
3 · Hydrothermal synthesis
These are the review authors’ synthesis, not newly measured results.
Planar 2D pi-conjugated MOF sheets are presented as especially effective conductive frameworks because metal-ligand pi-d interactions and delocalisation support high conductivity.
Evidence basis: multi_reference
Caveat: The review is descriptive and does not adjudicate anisotropy or defect effects in each material.
2 · Conductive MOFs commonly used for sensing
For gas sensing, conductive MOFs are described as transducing adsorption, absorption, or catalysis into resistance changes through framework interactions and redox processes.
Evidence basis: multi_reference
Caveat: The review stresses that surface area, binding-site accessibility, selectivity, and morphology also govern response.
5 · Gas sensors
Composites with metals, enzymes, aptamers, and graphene can enhance selectivity, sensitivity, stability, conductivity, and catalytic activity, but introduce added processing and attribution complexity.
Evidence basis: multi_reference
Caveat: The review is application-focused and generally does not separate intrinsic MOF conduction from composite contributions.
4 · Functionalization strategies of conductive MOFs
Conductive-MOF performance is interpreted through charge-carrier density and mobility; high conductivity requires both abundant weakly bound carriers and efficient charge transfer.
Evidence basis: multi_reference
Caveat: The review later warns that measured conductivity and mobility values can be misleading across methods and sample forms.
1 · Construction strategies for conductive MOFs
The review frames ordinary porous MOFs as commonly insulating because ligand spacing suppresses effective pi-pi stacking and low-energy charge-transfer pathways.
Evidence basis: multi_reference
Caveat: This is a broad review framing and does not replace primary conductivity measurements.
1 · Introduction
Electrochemical MOF sensing is attractive for fast, low-cost analysis but remains vulnerable to interfering electroactive species, pH effects, and competitive species.
Evidence basis: review_reasoning
Caveat: Claim is the review authors' synthesis across electrochemical examples.
8 · Biosensors
In FET sensors, conductive MOFs can serve as channel materials bridging source and drain electrodes while also providing pore-based recognition or screening.
Evidence basis: multi_reference
Caveat: Large-area undamaged films and stable electrode contact remain unresolved.
6 · Application of conductive MOFs in field-effect transistor (FET) sensors
The review repeatedly links sensor performance to film morphology, deposition method, gas diffusion, electrode interfaces, and MOF/composite hybridisation.
Evidence basis: multi_reference
Caveat: Mechanistic details differ by analyte, device format, and film geometry.
6 · Gas sensors
Guest molecules or nanoclusters can create new charge pathways or free charges in MOFs, but the review treats this as an extrinsic strategy rather than intrinsic framework conduction.
Evidence basis: multi_reference
Caveat: Useful for conductivity enhancement but may complicate attribution of transport to the MOF lattice itself.
1 · Construction strategies for conductive MOFs
Sensing ligands are described as needing conductivity, aromatic conjugation, active sites, analyte affinity, and chemical/thermal stability.
Evidence basis: single_reference
Caveat: This is a design heuristic rather than a measured universal rule.
2 · Conductive MOFs commonly used for sensing
The review explicitly warns that conductivity and charge-mobility comparisons can be deceptive because measurement methods, contact effects, anisotropy, inhomogeneity, sample form, and temperature matter.
Evidence basis: multi_reference
Caveat: This caveat is especially relevant when using review tables for chapter benchmarks.
9 · Conclusions and perspectives
The review presents 2D conductive MOFs as promising PEC photoactive materials because conductive ligands help absorb light, separate charge, and inhibit electron-hole recombination.
Evidence basis: multi_reference
Caveat: Poor selectivity from nonspecific photocatalysis remains a key limitation for PEC sensors.
9 · Application of conductive MOFs in photoelectric chemical sensing detection
Conductive MOFs are described as ion-to-electron transducers in potentiometric sensors because they combine electrical conductivity, capacitance, low contact resistance, and porous interfacial area.
Evidence basis: multi_reference
Caveat: The discussion is brief relative to electrochemical and chemiresistive sensing.
9 · Application of conductive MOFs for potentiometric ion detection
The review identifies large-scale synthesis, solvent/temperature burdens, morphology and pore-geometry control, water stability, and reproducibility as major barriers to conductive-MOF sensing.
Evidence basis: single_reference
Caveat: This is an outlook-level synthesis, not a quantified comparison across all materials.
10 · Conclusions and perspectives
Every row remains visibly secondary and links to a primary dossier only where the mapping is verified.
| Material | Property | Reported value | Context and quality | Primary evidence | Review source |
|---|---|---|---|---|---|
| SecondaryCoPc-Cu | nifedipine detection limit | 6.0 nM | electrochemical sensor; NIF tablets; linear range 0.01-92.55 uM Table · Exact Reported | research_0875 | 18 · Figures and tables · Table 1 |
| SecondaryCoxNi3-x(HITP)2 | enrofloxacin detection limit | 0.2 fg mL^-1 | aptasensor for ENR Table · Exact Reported | No verified corpus mapping | 18 · Figures and tables · Table 1 |
| SecondaryCu-MOF/CF | glucose detection limit | 0.076 uM | electrochemical sensor; human serum; linear range 0.001-0.95 mM Table · Exact Reported | research_0805 | 18 · Figures and tables · Table 1 |
| SecondaryNi-HAB | Li+ potentiometric detection limit | 9.94 x 10^-7 M | potentiometric ion detection Table · Exact Reported | No verified corpus mapping | 18 · Figures and tables · Table 1 |
| SecondaryNi3(HITP)2 | ascorbic acid detection limit | 1 uM | electrochemiluminescent sensor; human sweat; linear range 2-200 uM Table · Exact Reported | No verified corpus mapping | 18 · Figures and tables · Table 1 |
| SecondaryNi3(HITP)2 | H2S detection limit | 3 ppb | chemical resistance sensor; H2S; linear range 0.1-10 ppm Table · Exact Reported | research_0124 | 18 · Figures and tables · Table 1 |
| SecondaryNi-MOF@Ni-HHTP-5 | glucose detection limit | 0.02 uM | electrochemical sensor; linear range 0.5-2665.5 uM Table · Exact Reported | No verified corpus mapping | 18 · Figures and tables · Table 1 |
| Secondary[NixCo9-x(HHTP)4(H2O)30] | miRNA-141 detection limit | 0.69 fM | electrochemiluminescent sensor; lysates from 22Rv1 and MCF-7 cells; linear range 1 fM-10 nM Table · Exact Reported | research_0008 | 19 · Figures and tables · Table 2 |
| SecondaryNiPc-Cu-MOF | N-acetyl-L-cysteine detection limit | 50 nM | photoelectrochemical sensing; N-acetylcysteine tablets and capsules; linear range 0.0125-42.5 uM Table · Exact Reported | No verified corpus mapping | 19 · Figures and tables · Table 2 |
| Secondaryordinary porous MOFs | typical electrical conductivity | <10^-10 S cm^-1 | general statement for most nonconductive MOFs Text · Approximate | No verified corpus mapping | 1 · Introduction |
| SecondaryRu@Cu3(HHTP)2 | CRP detection limit | 0.26 pg/mL | electrochemiluminescent sensor; human serum; linear range 0.005-50 ng/mL Table · Exact Reported | No verified corpus mapping | 19 · Figures and tables · Table 2 |
| SecondaryZn-HHTP | CO detection limit | 10 ppm | FET sensor; CO; linear range 10-100 ppm Table · Exact Reported | research_0153 | 18 · Figures and tables · Table 1 |
Open questions are presented as review-author priorities, not conclusions from the primary database.
Aptamer-based conductive MOF biosensors require better sequence screening, characterisation, ligand stability, reliability in real samples, and rapid onsite pathogen detection.
Proposed direction: Treat recognition-element validation and real-sample robustness as part of MOF sensor design rather than post hoc demonstrations.
5 · Conductive MOF/aptamer composites
The review states that inconsistent conductivity-measurement methods and deceptive cross-study mobility or conductivity comparisons remain a major limitation.
Proposed direction: Standardise measurement protocols, report contact geometry and sample form, and separate intrinsic transport from device-contact artefacts.
9 · Conclusions and perspectives
The review calls for deeper understanding of deposition method, film morphology, electrode interfaces, secondary hybridisation, gas diffusion, and adsorption effects on sensing performance.
Proposed direction: Correlate controlled film morphology and interface chemistry with chemiresistive response, selectivity, and response/recovery kinetics.
6 · Gas sensors
Obtaining large-area undamaged conductive MOF films tightly integrated with substrates remains unresolved, especially for FET and thin-film gas sensors.
Proposed direction: Develop simple scalable film-growth strategies with controlled substrate contact, orientation, and minimal damage.
7 · Application of conductive MOFs in field-effect transistor (FET) sensors
PEC conductive MOF sensors can suffer poor selectivity because photocatalytic reactions on photoelectrodes are nonspecific.
Proposed direction: Develop less costly recognition strategies and clarify PEC mechanisms to improve selectivity without overly complex receptor modification.
9 · Application of conductive MOFs in photoelectric chemical sensing detection
The review identifies additional redox-active ligand research as necessary to expand conductive MOF sensing scope.
Proposed direction: Design ligands that combine extended conjugation, stable redox states, analyte recognition, and robust metal-ligand coupling.
10 · Conclusions and perspectives
Large-scale conductive MOF synthesis is hindered by high temperatures, toxic solvents, time-consuming processing, and poor control of morphology and pore geometry.
Proposed direction: Prioritise low-temperature, lower-toxicity, high-throughput synthesis routes with explicit morphology and pore-geometry control.
10 · Conclusions and perspectives
The review calls for deeper understanding of interactions between conductive MOFs and target substances, especially to improve selectivity.
Proposed direction: Combine in situ spectroscopy, electrochemical characterisation, and controlled binding-site design to connect analyte chemistry with transport response.
10 · Conclusions and perspectives
The review highlights humidity, water stability, and water solubility as practical constraints for sensors operating in realistic environments.
Proposed direction: Improve framework water stability and solvent compatibility while preserving conductivity and pore accessibility.
10 · Conclusions and perspectives
Mappings show which printed review references have a verified counterpart in the frozen primary corpus.
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|---|---|---|---|
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