Murray A., Valenti G., Baker P. · Electrochimica Acta · 2026 · 148350
Open a family to keep every result attached to its sample, method and conditions.
Paraphrased for this database from the authors’ stated interpretations — never quoted verbatim — and kept separate from reported measurements.
The Cu3(HHTP)2-modified SPCE ECL immunosensor detects cTnI over 0-80 pg/mL with LOD 10.23 +/- 1.06 pg/mL, below the 400 pg/mL clinical threshold cited by the authors.
Caveat: Demonstrated in buffer/in vitro; future studies are needed for real samples and long-term reproducibility.
p008-p009 · 3.7 Analytical performance; 4 Conclusion · Figure 9; Table 1 · Linked to 4 structured results
No delamination or sudden ECL signal decrease was observed under the study conditions, but long-term stability, reproducibility and real-sample selectivity remain future work.
Caveat: Short-term stability only; no extended stability dataset was reported.
p008-p009 · 3.7 Analytical performance; 4 Conclusion
In the final immunosensor, antibody immobilisation provides cTnI selectivity while Cu3(HHTP)2 acts as the conductive/redox-active transduction layer and BSA suppresses nonspecific adsorption.
Caveat: The authors state future work is needed to test selectivity in real samples, long-term stability and reproducibility.
p008 · 3.7 Analytical performance · Linked to 3 structured results
The synthesised powder is assigned as Cu3(HHTP)2, with XRD matching simulated diffraction data and FTIR/UV-Vis/TGA/Raman supporting the framework chemistry.
Caveat: No CIF or refined structural parameters were supplied with the assignment; phase assignment is based on authors' comparison to simulated pattern and literature.
p003-p004 · 3.1 Characterization · Figure 1 · Linked to 11 structured results
Drop-casting Cu3(HHTP)2 on SPCE increases surface roughness and creates a rougher, more porous electrode morphology favourable for electrochemical applications.
Caveat: Porosity and surface area are inferred from morphology and c-MOF description; no BET surface area or pore-size measurement is reported in the paper.
p004-p005 · 3.2 Morphological characterization · Figures 3-4 · Linked to 3 structured results
The Cu3(HHTP)2 layer facilitates charge transfer in [Ru(bpy)3]2+ solution, lowering the Nyquist semicircle relative to unmodified SPCE and enhancing ECL generation.
Caveat: EIS values here are visual estimates from Figure 7C; the paper does not provide fitted Rct numbers.
p006 · 3.4 Characterization of immunosensor · Figure 7C · Linked to 3 structured results
The HHTP ligand/redox-active Cu3(HHTP)2 framework is proposed to enable co-reactant-free anodic ECL by improving electron transfer and reducing electrochemically generated [Ru(bpy)3]3+ to the excited [Ru(bpy)3]2+* state.
Caveat: Mechanism is proposed from electrochemical/ECL observations and SI HHTP control; Figure S1 numeric values are visual estimates from the rendered SI page, not fitted/tabulated values.
p007 · 3.5 Possible ECL mechanism · Figure S1; Scheme S1 · Linked to 9 structured results
Names and aliases are kept exactly within the paper’s own identity model.
| Material | Composition | Structure context | Source |
|---|---|---|---|
| Cu3(HHTP)2 conductive metal-organic frameworkBrowse family: Cu₃(HHTP)₂ / Cu–HHTP | Cu3(HHTP)2Cu centres; discussion assigns mixed-valence Cu+/Cu2+ centres and Cu redox couples · 2,3,6,7,10,11-hexahydroxytriphenylene (HHTP) | 2D · Pristine2D pi-d conjugated conductive MOF; XRD peaks at 9.45, 12.56, 16.36, and about 28 deg assigned to (200), (210), (220), and (002) planes and matched simulated Cu3(HHTP)2. | p002-p003 · 2.3 Synthesis; 3.1 Characterization · Scheme 1; Figure 1A |
| HHTP ligand film on SPCE | HHTP on SPCE2,3,6,7,10,11-hexahydroxytriphenylene | 0D · Model SystemDrop-coated ligand film used as mechanistic control for ligand-centred redox/ECL behaviour. | p002 · Figure S1 note · Figure S1 |
| Screen-printed carbon electrode | carbon electrode | unknown · UnknownCommercial DropSens SPCE with 4 mm working electrode diameter, used as unmodified control and support. | p002 · 2.2 Instrumentation |
| Cu3(HHTP)2-modified screen-printed carbon electrodeBrowse family: Cu₃(HHTP)₂ / Cu–HHTP | Cu3(HHTP)2 drop-cast on SPCECu centres in Cu3(HHTP)2 · HHTP-derived dioxolene/catechol-quinone linker | 2D · CompositeComposite electrode comprising a Cu3(HHTP)2 layer on a screen-printed carbon electrode. | p002 · 2.4 Fabrication |
Sample form, processing state and composition status define the context for measurements.
| Sample | Form and role | Processing and geometry | Source |
|---|---|---|---|
| Cu3(HHTP)2 film on aluminium foilresearch_0899__mat__mat_cu3hhtp2 | Thin Film · Pristine Control · Pristine Framework | Cu3(HHTP)2 drop-cast on aluminium foil and dried overnight to form a film for Raman spectroscopy.aluminium foil | p004 · 3.1 Characterization · Figure 2 |
| Cu3(HHTP)2 blue-black powderresearch_0899__mat__mat_cu3hhtp2 | Powder · Composite Component · Pristine Framework | Solvothermal/solution reaction product dried in vacuum at 80 deg C for 24 h. | p002 · 2.3 Synthesis |
| Unmodified SPCEresearch_0899__mat__mat_spce | Electrode · Pristine Control · Unknown | Commercial SPCE used as received as electrochemical and ECL control.screen-printed carbon electrode | p002 · 2.2 Instrumentation |
| SPCE/Cu3(HHTP)2research_0899__mat__mat_spce_cu3hhtp2 | Electrode · Target Sample · Composite | Cu3(HHTP)2 aqueous dispersion drop-cast on SPCE and dried overnight at room temperature.SPCE · 15 uL of 2 mg/mL Cu3(HHTP)2 dispersion | p002 · 2.4 Fabrication |
| SPCE/Cu3(HHTP)2/Abresearch_0899__mat__mat_spce_cu3hhtp2 | Electrode · Composite Sample · Composite | SPCE/Cu3(HHTP)2 incubated with cTnI antibody at 1 ug/mL for 1 h at 4 deg C.SPCE | p002 · 2.4 Fabrication |
| SPCE/Cu3(HHTP)2/Ab/BSA immunosensorresearch_0899__mat__mat_spce_cu3hhtp2 | Electrode · Target Sample · Composite | SPCE/Cu3(HHTP)2/Ab blocked with 1 wt % BSA in PBS for 30 min at 4 deg C and rinsed with PBS.SPCE | p002 · 2.4 Fabrication |
| SPCE/HHTP ligand filmresearch_0899__mat__mat_hhtp | Electrode · Model System · Model | HHTP dissolved in acetone and drop-coated at SPCE to form a film.SPCE | p002 · Figure S1 note · Figure S1 |