Sensing Application — High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks

Measurement evidence

Sensing Application

High-performance field-effect transistor glucose biosensors based on bimetallic Ni/Cu metal-organic frameworks · Wang B., Luo Y., Gao L. et al. · Biosensors and Bioelectronics · 2021 · 112736

5 measurement groups · 16 results

Reported values remain attached to the sample, method, conditions, extraction quality and source location that produced them.

control glucose concentration tests

GA-Ni/Cu-MOFs (7:1)-FET · Electrode

Glucose response controls for GOD-GA-Ni-MOFs-FET, GA-Ni/Cu-MOFs (7:1)-FET and Ni/Cu-MOFs (7:1)-FET.

Atmosphere
PBS
Geometry
liquid-gated FET
Context
enzyme-free, monometallic and unmodified controls
Measurement source
6 · 3.3 · Fig. S12
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
control glucose responseGOD-GA-Ni-MOFs-FET gave non-continuous current change; GA-Ni/Cu-MOFs (7:1)-FET and Ni/Cu-MOFs (7:1)-FET showed poor responseText
Qualitative
6 · 3.3 · Fig. S12

chronoamperometric glucose concentration test with FET readout

GOD-GA-Ni/Cu-MOFs (7:1)-FET · Electrode

5 uL PBS blank followed by 5 uL glucose solutions from 1 uM to 50 mM; Vgs = -0.10 V and Vds = -0.10 V.

Atmosphere
PBS, pH 7.4
Geometry
liquid-gated FET glucose sensor
Context
functionalised target device
Measurement source
3,6 · 2.6; 3.3 · Fig. 4
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
prepared glucose solution concentrations1 uM, 10 uM, 50 uM, 100 uM, 500 uM, 1 mM, 5 mM, 10 mM, 20 mM and 50 mM in PBSText
Exact Reported
S2
tested glucose concentration range1 uM-50 mM tested; current response saturated above 20 mMText
Range
3,6 · 2.6; 3.3 · Fig. 4a,b
high-concentration sensitivity10.96 uA cm^-2 mM^-1 in 100 uM-20 mM glucoseText
Exact Reported
6 · 3.3 · Fig. 4c; Table 1
high-range linear fitMarked as a best value within this papery = 33.78 + 10.96x; R2 = 0.9968Text
Exact Reported
6 · 3.3 · Fig. 4c
low-range linear fity = 2.02 + 26.05x; R2 = 0.9896Text
Exact Reported
6 · 3.3 · Fig. 4c
linear glucose detection rangeMarked as a best value within this paper1 uM-20 mM, with two linear regions of 1-100 uM and 100 uM-20 mMText
Range
6-7 · 3.3 · Fig. 4c; Table 1
limit of detectionMarked as a best value within this paper0.51 uMText
Exact Reported
6-7 · 3.3; Conclusion · Table 1; Formula S2
low-concentration sensitivityMarked as a best value within this paper26.05 uA cm^-2 mM^-1 in 1-100 uM glucoseText
Exact Reported
6 · 3.3 · Fig. 4c; Table 1
response timeMarked as a best value within this paperdid not exceed 5 s<=Text
Approximate
6 · 3.3 · Fig. 4a inset

three-device glucose concentration reproducibility test

GOD-GA-Ni/Cu-MOFs (7:1)-FET · Electrode

Glucose concentration tests of three GOD-GA-Ni/Cu-MOFs (7:1)-FET devices under the same condition.

Atmosphere
PBS
Geometry
liquid-gated FET
Context
functionalised target device
Measurement source
3,7 · 2.6; 3.3 · Fig. S15
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
three-device reproducibility RSDMarked as a best value within this paper3.32%Text
Exact Reported
7 · 3.3 · Fig. S15

specificity/interference test

GOD-GA-Ni/Cu-MOFs (7:1)-FET · Electrode

100 uM glucose and interfering substances including sucrose, fructose, uric acid, ascorbic acid, galactose and lactose added sequentially.

Atmosphere
PBS
Geometry
liquid-gated FET
Context
functionalised target device
Measurement source
3,7 · 2.6; 3.3 · Fig. 5a; Fig. S16
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
specificity against interferencesMarked as a best value within this paperCurrent decreased significantly when glucose was added; sucrose, fructose, UA, AA, galactose and lactose did not change current sequentiallyText
Qualitative
7 · 3.3 · Fig. 5a; Fig. S16

short-term stability and storage lifetime tests

GOD-GA-Ni/Cu-MOFs (7:1)-FET · Electrode

Sensor kept under constant temperature and humidity; glucose response tested every two days for one week and after 0, 1, 2 and 3 weeks.

Atmosphere
constant temperature and humidity conditions
Geometry
liquid-gated FET
Context
functionalised target device
Measurement source
3,7 · 2.6; 3.3 · Fig. 5b,c; Fig. S17
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
three-week storage lifetimeAfter three weeks the current was significantly reduced and glucose response became weakerText
Qualitative
7 · 3.3 · Fig. S17
current signal loss after 2 days2.12%Text
Exact Reported
7 · 3.3 · Fig. 5c
current signal loss after 4 days16.72%Text
Exact Reported
7 · 3.3 · Fig. 5c
current signal loss after 6 days20.60%Text
Exact Reported
7 · 3.3 · Fig. 5c