cMOF Evidence Base
Electrochemistry Application — Piezoelectric-mediated two-dimensional copper-based metal–organic framework for synergistic sonodynamic and cuproptosis-driven tumor therapy

Measurement evidence

Electrochemistry Application

Piezoelectric-mediated two-dimensional copper-based metal–organic framework for synergistic sonodynamic and cuproptosis-driven tumor therapy · Zhong X., Li X., Gu L. et al. · Journal of Colloid and Interface Science · 2025 · 354-363

2 measurement groups · 6 results

Reported values remain attached to the sample, method, conditions, extraction quality and source location that produced them.

DTNB GSH depletion and TMB hydroxyl-radical kinetics assays

CM nanosheets · Nanosheet

GSH depletion at pH 5.5 using DTNB; TMB assay with CM, H2O2 and GSH at pH 5.5 or 7.4 after 12 h incubation.

Temperature
310
Atmosphere
PBS buffer
Context
PVP-coated Cu-2MI composite
Measurement source
9-10. In Vitro Glutathione Depletion; Kinetics of Hydroxyl Radical Production · Fig. 3f-i; Fig. S13
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
TMB absorbance at pH 5.5 relative to pH 7.4four times higher at pH 5.5 than at pH 7.4——Text
Rounded Reported		p004 · 2.3 SDT and CDT performance evaluation · Fig. 3g-i

ROS probe assays and ESR under ultrasound

Electron paramagnetic resonance

CM nanosheets · Nanosheet

DPA, NBT, MB, DPBF and ESR spin-trapping assays under ultrasound; CM concentration typically 60 ug mL^-1; ultrasound 1 MHz, 1 W cm^-2, 60% duty cycle for optical probes.

Atmosphere
aqueous solution
Context
PVP-coated Cu-2MI composite sonosensitizer
Measurement source
SI S13-S14; main p004-p005 · 5-8. ROS detection · Fig. 3b-d; Fig. S10-S12
PropertyReported valueNormalised valueUncertaintyOrigin and qualitySource
CM-DPBF absorbance peak near 420 nm after 120 s ultrasoundabout 1.0 a.u.—visual estimate from SI plotVisual Estimate
Approximate		S13 · Supplementary figures · Fig. S10a
CM-DPBF absorbance peak near 420 nm at 0 sabout 1.5 a.u.—visual estimate from SI plotVisual Estimate
Approximate		S13 · Supplementary figures · Fig. S10a
CM sonodynamic effect versus ZIF-8CM was superior to ZIF-8——Text
Qualitative		p004 · 2.3 SDT and CDT performance evaluation · Fig. S10
DPA absorbance decrease under US with CMabsorption peaks of DPA significantly reduced under US irradiation——Qualitative
Qualitative		p004-p005 · 2.3 SDT and CDT performance evaluation · Fig. 3b
NBT absorbance decrease under US with CMabsorption peaks of NBT significantly reduced under US irradiation——Qualitative
Qualitative		p004-p005 · 2.3 SDT and CDT performance evaluation · Fig. 3c