Le K.T.M., Nguyen C.M., Jamali S. et al. · Advanced Materials Technologies · 2026 · e01751
Open a family to keep every result attached to its sample, method and conditions.
Paraphrased for this database from the authors’ stated interpretations — never quoted verbatim — and kept separate from reported measurements.
The aptamer-functionalised CuHITP EG-FET detects cortisol down to 0.1 fM over an 11-order dynamic range with strong selectivity over glucose, serotonin and dopamine.
Caveat: Calibration was performed in controlled 0.01X PBS, not complex real biofluids.
9 · 3. Conclusion · Linked to 8 structured results
Wearable or clinical translation still requires temperature-dependence studies, long-term stability tests and validation in complex biological matrices.
Caveat: Authors explicitly identify these as future work.
9 · 3. Conclusion
Intrinsic -NH- groups in CuHITP enable covalent MBS coupling and stable attachment of thiolated aptamers without adding a separate MOF-disrupting functionalisation chemistry.
Caveat: Direct bond chemistry is inferred from the designed MBS/NH reaction and surface evidence rather than direct molecular spectroscopy of the bond.
7 · 2.3.1 Formation of Functional Groups · Figure 5 · Linked to 5 structured results
Raw SI EDS tables support the transformation from Cu(OH)2 to CuHITP by the emergence of N and high C, and support aptamer attachment by the appearance of P after functionalisation.
Caveat: EDS is compositional and does not by itself prove bonding; assignment relies on the paper's accompanying XPS/XRD and functionalisation chemistry.
5-6 · Supporting Information · Figures S5-S7 · Linked to 3 structured results
The on-chip solid-phase reaction only partially converts Cu(OH)2, giving a CuHITP/Cu(OH)2 heterostructure rather than a fully pristine CuHITP film.
Caveat: Residual Cu(OH)2 may be beneficial as scaffold; exact phase fraction is not quantified.
4 · 2.1 Material Characterization · Figure 2c · Linked to 4 structured results
The hydroxide-template conversion promotes vertical alignment and a robust electrical interface, improving mass transport and analyte access compared with randomly aggregated drop-cast films.
Caveat: Mass transport is argued mechanistically; no direct diffusion coefficient is reported.
4 · 2.1 Material Characterization · Linked to 3 structured results
CuHITP provides a semiconducting, more conductive transduction pathway than insulating MOFs, supporting efficient EG-FET sensing.
Caveat: The provided SI text does not include the S8 conductivity plot; the 0.2 S cm-1 value is text-reported but phrased as 'reported conductivity'.
9 · 3. Conclusion/discussion before conclusion · Linked to 4 structured results
Names and aliases are kept exactly within the paper’s own identity model.
| Material | Composition | Structure context | Source |
|---|---|---|---|
| MBS/aptamer-functionalised CuHITP sensing interfaceBrowse family: Cu₃(HITP)₂ / Cu–HITP | CuHITP/Cu(OH)2-MBS-DNA aptamerCuHITP conductive MOF nodes with MBS-linked thiolated DNA aptamer · HITP framework plus MBS crosslinker and thiolated cortisol or scrambled DNA aptamer | 2D · CompositeCovalently biofunctionalised conductive-MOF heterostructure surface for EG-FET sensing. | 7 · 2.3.1 Formation of Functional Groups · Figure 5a |
| patterned copper electrode template | Cumetallic copper film · none | unknown · UnknownE-beam evaporated Cu layer patterned on Si-based electrode stack before oxidation to Cu(OH)2. | 9 · 4. Experimental Section |
| vertically aligned CuHITP/Cu(OH)2 heterostructure filmBrowse family: Cu₃(HITP)₂ / Cu–HITP | CuHITP on residual Cu(OH)2Cu2+ coordinated to N atoms in CuHITP; residual Cu(OH)2 core · HITP = 2,3,6,7,10,11-hexaiminotriphenylene, formed from HATP.6HCl precursor | 2D · CompositePartially converted, vertically aligned 2D conductive CuHITP outer layer on residual Cu(OH)2 nanoarray scaffold; XRD contains both Cu(OH)2 and CuHITP peaks. | 4 · 2.1 Material Characterization · Figure 2c |
| powder CuHITP controlBrowse family: Cu₃(HITP)₂ / Cu–HITP | CuHITPCu coordinated to imine/amine N sites of HITP · HITP = 2,3,6,7,10,11-hexaiminotriphenylene | 2D · PristineControl CuHITP powder synthesised by a conventional solvothermal method and compared by XRD. | 3 · Figure 2 caption · Figure 2c |
| Cu(OH)2 nanoarray template | Cu(OH)2Cu hydroxide nanoarray · none | 1D · UnknownVertically aligned tubular Cu(OH)2 nanoarray used as solid-phase template for CuHITP conversion. | 1 · Abstract |
Sample form, processing state and composition status define the context for measurements.
| Sample | Form and role | Processing and geometry | Source |
|---|---|---|---|
| patterned Cu electrode on p-type Si(100)research_0590__mat__cu_metal_template | Electrode · Pristine Control · Unknown | Patterned electrode before Cu(OH)2 nanoarray growth.p-type Si(100) wafer, single-side polished, 1-10 ohm cm; Al/Ni and Ti/Cu patterned contacts · 10 nm Al / 60 nm Ni / 10 nm Ti / 250 nm Cu metal stack | 9 · 4. Experimental Section |
| cortisol-aptamer-functionalised CuHITP EG-FET sensorresearch_0590__mat__aptamer_functionalised_cuhitp | Electrode · Target Sample · Guest Loaded | MBS-coupled electrode functionalised overnight with thiolated cortisol aptamer, then blocked with MCH and BSA.CuHITP/Cu(OH)2 extended-gate electrode on patterned Si device connected to p-channel MOSFET · not reported | 10 · 4. Experimental Section |
| CuHITP/Cu(OH)2 extended-gate electroderesearch_0590__mat__cuhitp_cuoh2_heterostructure | Electrode · Target Sample · Composite | Solid-phase conversion of pre-patterned Cu(OH)2 nanoarray to black CuHITP/Cu(OH)2 heterostructure; rinsed and vacuum dried.patterned p-type Si(100) electrode with Al/Ni/Ti/Cu contacts; used as EG-FET sensing electrode · not directly reported; SEM tubular width about 200 nm after conversion; SI S12 compares 1, 3, 5 and 15 min conversion thickness/performance visually. | 10 · 4. Experimental Section |
| isolated CuHITP film fragment converted on Cu foilresearch_0590__mat__cuhitp_cuoh2_heterostructure | Thin Film · Target Sample · Composite | Similar templated synthesis on Cu foil; mechanical bending caused CuHITP film delamination.converted on Cu foil, then delaminated by bending for two-point probe measurement · not reported | 7 · Figure captions · Figure S8 |
| MBS-functionalised CuHITP/Cu(OH)2 electroderesearch_0590__mat__aptamer_functionalised_cuhitp | Electrode · Composite Sample · Composite | CuHITP sensing surface incubated with MBS crosslinker before aptamer attachment.CuHITP/Cu(OH)2 extended-gate electrode on patterned Si device · not reported | 10 · 4. Experimental Section |
| solvothermal CuHITP powder controlresearch_0590__mat__cuhitp_powder_control | Powder · Pristine Control · Pristine Framework | Prepared using conventional solvothermal method for XRD comparison; recipe not disclosed in available text.none · not applicable | 4 · 2.1 Material Characterization · Figure 2c |
| scrambled-aptamer-functionalised CuHITP EG-FET control sensorresearch_0590__mat__aptamer_functionalised_cuhitp | Electrode · Pristine Control · Guest Loaded | MBS-coupled electrode functionalised with a thiolated scrambled aptamer sequence of similar length and GC content.CuHITP/Cu(OH)2 extended-gate electrode on patterned Si device connected to p-channel MOSFET · not reported | 9 · 4. Experimental Section |
| Cu(OH)2 nanoarray on patterned electroderesearch_0590__mat__cuoh2_nanoarray | Electrode · Pristine Control · Unknown | Grown by oxidative alkaline treatment of the patterned Cu layer with APS/NaOH solution.patterned p-type Si(100) electrode with Al/Ni/Ti/Cu contacts · not reported; SEM tubular width about 100 nm | 9 · 4. Experimental Section |